Reciprocal interference of maternal and infant immunization in protection against pertussis |
| |
| Affiliation: | 1. Univ Lille, U1019—UMR 8204—CIIL—Centre d’Infection et d’Immunité de Lille, F-59000 Lille, France;2. CNRS, UMR 8204, F-59000 Lille, France;3. Inserm, U1019, F-59000 Lille, France;4. CHU Lille, F-59000 Lille, France;5. Institut Pasteur de Lille, F-59000 Lille, France;1. Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Liuzhou Municipal Center for Disease Control and Prevention, Liuzhou 545007, Guangxi, China;3. Shenzhen Kangtai Biological Products Co., LTD., Shenzhen 518057, Guangdong, China;4. Guangxi Provincial Centers for Disease Control and Prevention, Nanning 530028, Guangxi, China;1. Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;2. Division of Swine Medicine of the Department for Farm Animals, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;3. Division of Veterinary Epidemiology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;1. Institute for Translational Vaccinology (InTraVacc), Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands;2. Immunology of Infectious Diseases and Vaccines (IIV), National Institute of Public Health and the Environment, Antonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, The Netherlands;3. Department of Internal Medicine, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands;1. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands;2. Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands;1. Novartis Vaccines and Diagonstics SrL (a GSK Company), Via Fiorentina 1, 53100 Siena, Italy;2. Università degli Studi di Padova, 35129 Padova, Italy;3. Università di Siena, 53100 Siena, Italy;4. GlaxoSmithKline (former Novartis Vaccines), 350 Massachusetts Ave, Cambridge, 02139 MA, USA |
| |
| Abstract: | ![]()
BackgroundBecause of the current re-emergence of pertussis, vaccination during the 3rd trimester of pregnancy is recommended in several countries in order to protect neonates by placental transfer of maternal antibodies. Here, we examined the potential reciprocal interference of mother and infant vaccination in protection against pertussis in mice.MethodsFemale mice were vaccinated with acellular pertussis vaccines and protection against Bordetella pertussis challenge, as well as functional antibodies were measured in their offspring with or without re-vaccination.ResultsMaternal immunization protected the offspring against B. pertussis challenge, but protection waned quickly and was lost after vaccination of the infant mice with the same vaccine. Without affecting antibody titers, infant vaccination reduced the protective functions of maternally-derived antibodies, evidenced both in vitro and in vivo. Protection induced by infant vaccination was also affected by maternal antibodies. However, when mothers and infants were immunized with two different vaccines, no interference of infant vaccination on the protective effects of maternal antibodies was noted.ConclusionIt may be important to determine the functionality of antibodies to evaluate potential interference of maternal and infant vaccination in protection against pertussis. |
| |
| Keywords: | Pertussis Acellular vaccine Whole-cell vaccine Maternal immunization Antibodies |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
