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Reduced serologic sensitivity to influenza A virus illness among inactivated influenza vaccinees
Institution:1. Influenza Division/NCIRD/CDC, Atlanta, GA 30333, United States;2. Division of Pediatric Infectious Diseases, Baylor Scott & White Health, Texas A&M HSC COM, Temple, TX 76508, United States;3. The Center for Health Research, Kaiser Permanente Northwest, Portland, OR 97227, United States;4. Abt Associates, Cambridge, MA 02138, United States;1. Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, China;2. West China School of Medicine, Sichuan University, Chengdu, China;3. Sichuan Key Laboratory of Medical American Cockroach, Chengdu, China;4. Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu, China;1. Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA;2. Department of Family Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;3. Division of Prevention and Primary Care, New York City Department of Health and Mental Hygiene, Gotham Center, Long Island City, NY, USA;4. Communicable Disease Service Infectious and Zoonotic Disease, New Jersey Department of Health, Trenton, NJ, USA;5. Minnesota Department of Health, St Paul, MN, USA;6. Bureau of Epidemiology, Florida Department of Health, Tallahassee, FL, USA;7. Division of Disease Control, North Dakota Department of Health, Bismarck, ND, USA;8. Public Health Preparedness and Epidemiology Program, Texas Department of Health, Temple, TX, USA;9. Acute Communicable Disease Control Program, Los Angeles County Department of Public Health, Los Angeles, CA, USA;10. Division of Disease Control, Philadelphia Department of Public Health, Philadelphia, PA, USA;11. Center for Acute Disease Epidemiology, Iowa Department of Public Health, Des Moines, IA, USA;12. Division of Surveillance and Investigation, Virginia Department of Health, Richmond, VA, USA;13. Acute and Communicable Disease Program, Oregon Public Health Division, Portland, OR, USA;14. Division of Disease Control and Prevention, Utah Department of Health, Salt Lake City, UT, USA;15. Council of State and Territorial Epidemiologists, Atlanta, GA, USA;1. State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China;2. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China;3. Key Laboratory of Molecular Microbiology and Biotechnology (Ministry of Education) and Key Laboratory of Microbial Functional Genomics (Tianjin), College of Life Sciences, Nankai University, Tianjin, China;4. School of Medicine, Nankai University, Tianjin, China;1. Núcleo de Biotecnologia, Universidade Federal do Espírito Santo – UFES, Vitória, Brazil;2. Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo – UFES, Vitória, Brazil;3. Departamento de Medicina Veterinária, Universidade Federal do Espírito Santo – UFES, Alegre, Brazil;4. Instituto de Biofísica Carlos Chagas Filho – Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil;1. WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia;2. Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA;3. Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia;4. WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China
Abstract:We compared ≥4-fold increases in antibody titers by hemagglutination inhibition assay to RT-PCR results among 42 adults with PCR-confirmed influenza A virus illnesses. Serologic sensitivity was higher among unvaccinated (69%, 95% confidence interval CI] = 48–90%) than vaccinated healthcare personnel (38%, 95% CI = 29–46%) in a 2010–11 prospective cohort.
Keywords:Influenza  Hemagglutinin inhibition  Seroconversion  Antibody  Influenza vaccine  Immunogenicity  Vaccine failure
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