The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps |
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| Affiliation: | 1. World Health Organization, Geneva, Switzerland;2. National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA;3. Wits Reproductive Health and HIV Institute, University of the Witswatersrand, Johannesburg, South Africa;4. Centers for Disease Control and Prevention, Atlanta, GA, USA;5. University of Washington, Seattle, WA, USA;6. University of Sunshine Coast, Queensland Australia and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia;7. University of Toronto, Toronto, ON, Canada;8. Uniformed Services University, Bethesda, MD, USA;9. University of Victoria, Victoria, BC, Canada |
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| Abstract: | In 2014, the World Health Organization, the US National Institutes of Health, and global technical partners published a comprehensive roadmap for development of new vaccines against sexually transmitted infections (STIs). Since its publication, progress has been made in several roadmap activities: obtaining better epidemiologic data to establish the public health rationale for STI vaccines, modeling the theoretical impact of future vaccines, advancing basic science research, defining preferred product characteristics for first-generation vaccines, and encouraging investment in STI vaccine development. This article reviews these overarching roadmap activities, provides updates on research and development of individual vaccines against herpes simplex virus, Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum, and discusses important next steps to advance the global roadmap for STI vaccine development. |
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| Keywords: | Sexually transmitted infections Vaccines STI vaccine development Roadmap |
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