| 78例急性药物性肝损害临床分析 |
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| 引用本文： | 张国龙,朱祖明. 78例急性药物性肝损害临床分析[J]. 药学与临床研究, 2010, 18(5): 482-483 |
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| 作者姓名： | 张国龙 朱祖明 |
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| 作者单位： | 1. 南京医科大学附属江宁医院,药剂科,南京,211100
2. 南京医科大学附属江宁医院,消化科,南京,211100 |
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| 摘 要： | 回顾分析我院2006年6月-2010年6月期间78例急性药物性肝损害患者的临床特点.引起急性药物性肝损害的药物:第一位是中草药(28/78,35.9%);其次为抗结核药 (11/78,14.1%)、抗菌药物 (10/78,12.8%)等.肝损害的临床分型中,肝细胞损伤型占51.3%(40/78),胆汁淤积型占16.7%(13/78),混合型占32.0%(25/78),临床表现无特异性.
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| 关 键 词： | 急性药物性肝损害 回顾性分析 临床特点 |
| 收稿时间： | 2010-07-10 |
| 修稿时间： | 2010-08-02 |
Analysis of 78 Patients with Drug-induced Acute Hepatic Lesions |
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| ZHANG Guo-Long and ZHU Zu-Ming. Analysis of 78 Patients with Drug-induced Acute Hepatic Lesions[J]. Pharmacertical and Clinical Research, 2010, 18(5): 482-483 |
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| Authors: | ZHANG Guo-Long and ZHU Zu-Ming |
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| Affiliation: | Department of Pharmacology, Affiliated JiangNing Hospital of Nanjing Medical University, Nanjing 211100, China;Department of Gastroenterology, Affiliated JiangNing Hospital of Nanjing Medical University, Nanjing 211100, China |
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| Abstract: | The clinical data of 78 drug-induced acute hepatic lesion cases collected from Jun. 2006 to Jun. 2010 in our hospital were analyzed retrospectively. Among the therapeutic agents that might cause the liver dysfunctions, the highest incidence rate was due to Chinese herbal medicines (28/78, 35.9%), followed by anti-tuberculosis agents (11/78, 14.1%), antibiotics(10/78, 12.8%), et al. Judging from clinical manifestations, 51.3% (40/78) were hepatocellular damage, 16.7% (13/78) cholestatic damage and 32.0% (25/78) mixed type damage, which varies little from other causes. |
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| Keywords: | Drug-induced acute hepatic lesions Retrospective analysis Clinical feature |
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