青蒿素类药物抗肿瘤作用的基础与临床研究

青蒿素类(Art)抗疟药具有多种药理活性,近年来对其抗肿瘤作用的基础研究较多,相关的临床研究也逐渐开展。大量体外和动物体内实验结果显示:Art可抑制或杀伤肿瘤细胞;诱导肿瘤细胞凋亡:阻滞细胞周期;抑制血管生成;延缓或逆转肿瘤细胞的多药耐药性;与铁制剂合用或与转铁蛋白结合可提高对肿增细胞的选择性杀伤作用。临床探索提示Art对肿瘤具有治疗或辅助治疗作用。Art对人体毒性低,与传统化学治疗药物有协同增效作用且无交叉耐药性。应加强Art抗肿瘤的临床研究以明确其抗肿瘤性质、范围、剂量、疗程及不良反应。

Basic and clinical researches on antitumor effects of antimalarial artemisinin and its derivatives

Antimalarial artemisinin and its derivatives(Art)possess various kinds of pharmacological activities,the correlative clinical researches are gradually carrying on along with a lot of antineoplastic basic studies.Large number of studies in vitro and in vivo has showned that Art can inhibit or kill tumor cells simultaneously with inducing the apoptosis of tumor cells,inhibiting angiogenesis and blocking the cell cycle. They can also delay or reverse the multi-drug resistance(MDR)of tumor cells.Moreover,if used with iron preparation or in combination with transferrin,Art can enhance the selective inhibitory effects to tumor cells. The clinical exploration suggested that Art was probably an antitumor agent or adjuvant in the treatment of tumors with low toxicity,and no cross-resistance and a synergistic effect with other traditional antitumor drugs. Strengthening the clinical researches of Art is needed for further clearing the nature,scope,dosage,and adverse effects in the antitumor treatment.