| 抑制核因子-κB受体活化因子及其配体通路治疗牙周炎的研究进展 |
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| 引用本文： | 陈斌[综述] 孙卫斌[审校]. 抑制核因子-κB受体活化因子及其配体通路治疗牙周炎的研究进展[J]. 国外医学:口腔医学分册, 2012, 0(1): 101-104 |
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| 作者姓名： | 陈斌[综述] 孙卫斌[审校] |
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| 作者单位： | 南京大学医学院附属口腔医院牙周科,南京210008 |
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| 基金项目： | 南京市卫生局青年科技人才启动基金资助项目（QYK-10166）;南京市留学回国人员科技活动基金资助项目（人社厅发[2008]86） |
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| 摘 要： | 核因子-κB受体活化因子（RANK）及其配体（RANKL）在牙周炎患者的牙槽骨吸收中具有重要的作用，抑制RANKL／RANK通路，可有效抑制破骨细胞的分化和激活，从而抑制牙槽骨的吸收。骨保护蛋白（OPG）和RANKL结合，干扰RANKL和RANK的结合，从而防止骨组织的过度破坏。本文就RANKL／RANK／OPG轴、RANKL／RANK／OPG与牙周炎、抑制RANKL／RANK通路治疗牙周炎的可行性等研究进展作一综述。
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| 关 键 词： | 核因子-κB受体活化因子／核因子-κB受体活化因子配体通路 牙周治疗 牙槽骨吸收 |
Research advances on inhibition receptor activator of nuclear factor-KB and. its ligand in periodontal treatment |
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| Affiliation: | Chen Bin, Sun Weibin. (Dept. of Periodontics, The Affiliated Stomatological Hospital of Medical College, Nanjing University, Nanjing 210008, China) |
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| Abstract: | Receptor activator of nuclear factor-κB （RANK） /receptor activator of nuclear factor-κB ligand（RANKL） play a critical role in alveolar bone resorption though affecting osteoclasts formation and activation, therefore,we can inhibit periodontal bone resorption though RANKL/RANK inhibition. Osteoprotegerin （OPG） protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. In this paper, we will review the relationship between RANKURANK/OPG signaling pathway and periodontal disease, and we will mainly focus on the possibility of periodontal treatment with RANKL/RANK inhibition. |
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| Keywords: | receptor activator of nuclear factor-κB/receptor activator of nuclear factor-κB ligand pathway periodontal treatment periodontal bone resorption |
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