| 橙皮苷与氨基胍对STZ－糖尿病大鼠主动脉胶原非酶糖化作用的比较 |
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| 引用本文： | 王新嘉,何国芬,张志利,杨静. 橙皮苷与氨基胍对STZ－糖尿病大鼠主动脉胶原非酶糖化作用的比较[J]. 中国糖尿病杂志, 1994, 0(4) |
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| 作者姓名： | 王新嘉 何国芬 张志利 杨静 |
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| 作者单位： | 山西医学院第二附属医院内科研究生，山西医学院第一附属医院内分泌科 |
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| 摘 要： | 本文观察了天然黄酮类化合物──橙皮苷对ＳＴＺ－糖尿病大鼠主动脉胶原非酶糖基化作用的影响，并与氨基肌进行了比较。结果表明：用橙皮苷及氨基肌治疗１２０天后，糖尿病鼠动脉胶原ＡＧＥｓ含量明显降低（Ｐ＜０．０１），而血糖、体重无明显差别。提示橙皮苷对糖尿病大鼠蛋白非酶糖基化作用与氨基胍相似。
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| 关 键 词： | 糖尿病，实验性，非酶糖基化，主动脉 |
A comparison of the effects of hespridin and aminoguanidine on aortic collagen nonenzymatic glycosylation in STZ-induced diabetic rats |
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| Wang Xin-jia,He Guo-fen,Zhang Zhi-li,et al. A comparison of the effects of hespridin and aminoguanidine on aortic collagen nonenzymatic glycosylation in STZ-induced diabetic rats[J]. Chinese Journal of Diabetes, 1994, 0(4) |
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| Authors: | Wang Xin-jia He Guo-fen Zhang Zhi-li et al |
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| Abstract: | This study compared the effect of hespridin, a natural flavonoids, on aortic collagen nonenzymatic glycosylation, with aminoguanidine in STZ-diabetic rats. After 120 days of treatment, the aortic collagen AGEs were significantly reduced in both groups(P<0.01),but the blood glucose and body weight were of no difference. These finding suggest that hespridin has a similar effect on inhibition of protein nonenzymatic glycosylation in STZ-diabetic rats as aminoguanidine. |
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| Keywords: | Experimental diabetes Nonenzymatic glycosylation Aorta |
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