慢性阻塞性肺疾病患者深吸气量与生命质量的关系

目的 探讨COPD患者深吸气量等肺功能指标与生命质量的关系.方法 2006年1月至2007年3月北京大学第三医院门诊的COPD稳定期患者62例,其中男55例,女7例;年龄43～79岁,平均年龄(66±8)岁.均进行肺容量、肺通气功能和小气道功能检查,并经圣乔治呼吸问卷(SGRQ)评分,采用Pearson直线相关分析SGRQ的分值与总分、SGRQ评分与肺功能指标之间的相关性.结果 62例COPD稳定期患者的SGRQ总分为(43±17)分,其中呼吸症状分值为(54±23)分,活动受限分值为(54±19)分,疾病影响分值为(33±20)分;肺功能检查结果中FEV_1占预计值%为(43±13)%,FEV_1/FVC为(52±11)%,残气量占预计值%为(194±50)%,残气量/肺总量为(166±31)%,深吸气量占预计值%为(74±21)%.深吸气量占预计值%、残气量占预计值%、残气量/肺总量、FEV,占预计值%、FEV./FVC、呼气峰流量、用力呼出50%肺活量时呼气流量(FEF_(50%))、用力呼出25%肺活量时呼气流量(FE_(25%))和最大呼气中段流量(MMEF)与SGRQ总分均呈负相关,其中通气功能指标的相关系数为-0.336～-0.479,小气道功能指标的相关系数为-0.368～-0.411,而深吸气量占预计值%和SGRQ的3个能区分值和总分相关性最好,相关系数为-0.418～-0.521,均P＜0.05.SGRQ的3个能区分值中呼吸症状和肺功能无显著相关性.结论 肺功能检查中肺容量测定、肺通气功能和小气道功能均与COPD患者的生命质量相关,深吸气量占预计值%和FEV_1占预计值%应联合作为临床评价COPD患者的客观指标.

Correlation of the quality of life with the inspiratory capacity in patients with chronic obstructive pulmonary disease

Objective To evaluate the correlation of the quality of life in patients with chronic obstructive pulmonary disease (COPD) with the lung function tests,especially the inspiratory capacity (IC).Methods Sixty-two stable COPD patients were enrolled between Jan.2006 and Mar.2007 (55 males and 7 females),with an age range of 43-79 (66±8) years.Lung volume,spirometry and small airway function measurements were performed in all patients.The St George respiratory questionnaire (SGRQ) score was collected.Pearson' s correlation coefficients were calculated.Results The total score of the 62 COPD patients was 43±17.The 3 component scores were:symptoms (54±23),activity (54±19) and impact (33±20).The FEV_1 pred% was (43±13)%,FEV_1/FVC was (52±11)%,residual volume (RV) pred% was (194±50)%,RV/total lung capacity (TLC) was (166±31)%,and IC pred% was (74±21)%.The SGRQ scores were significantly correlated with IC pred%,RV pred%,RV/TLC,FEV_1 pred%,FEV_1/FVC and small airway function measurements (FEF_(50%),FEF_(25%),MMEF).The correlation coefficients between the parameters of spirometry and the total score of SGRQ were-0.336 to-0.479,while those between the parameter of small airway function and the total score of SGRQ were-0.368 to -0.411.Among all these lung function measurements,ICpred% was best correlated with the SGRQ score,and the correlation coefficients between the IC pred% and the total score and the other 3 component scores of SGRQ were-0.418 to-0.521,respectively,P ＜ 0.05.The symptoms section score had the poorest correlation with the lung function test.Conclusions The lung function test results correlate with the quality of life in patients with COPD.IC pred %,together with FEV_1 pred% should be used for clinical evaluation of patients with COPD.