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| 定量PCR技术检测增生性瘢痕组织纤维连接蛋白的基因表达 | |
| 引用本文： | 杨银辉,付小兵,王亚平,孙同柱,许明火,盛志勇. 定量PCR技术检测增生性瘢痕组织纤维连接蛋白的基因表达[J]. 中华烧伤杂志, 1998, 0(6) |
| 作者姓名： | 杨银辉 付小兵 王亚平 孙同柱 许明火 盛志勇 |
| 作者单位： | 解放军第三○四医院创伤研究室 100037北京 |
| 基金项目： | 国家杰出青年科学基金资助 |
| 摘 要： | 目的探讨纤维连接蛋白的表达水平与创伤后增生性瘢痕形成的关系。方法采用定量PCR技术,对纤维连接蛋白(Fibronectin,FN)在正常皮肤和增生性瘢痕中mRNA表达水平的变化进行比较。结果在增生性瘢痕中,FN的mRNA表达水平较正常皮肤增高。结论实验结果表明细胞外基质成分的变化在创伤修复失控形成中起重要作用。 |
| 关 键 词： | 创伤修复 纤维连接蛋白 增生性瘢痕 定量PCR |
Fibronectin mRNA expression in hypertrophic scars |
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| Yang Yinhui,Fu Xiaobing,Wang Yaping,et al,Wound Healing Unit,Burns Institute. Fibronectin mRNA expression in hypertrophic scars[J]. Chinese journal of burns, 1998, 0(6) | |
| Authors: | Yang Yinhui Fu Xiaobing Wang Yaping et al Wound Healing Unit Burns Institute |
| Affiliation: | Yang Yinhui,Fu Xiaobing,Wang Yaping,et al,Wound Healing Unit,Burns Institute,The 304th Hospital,Beijing 100037 |
| Abstract: | Objective This study was to compare the content of fibronectin messenger RNA in the normal skin and hypertrophic scars. Method The mRNA levels of fibronectin were measured by quantitative RT-PCR. Result The study revealed that in vivo, the content of fibronectin messenger RNA was higher in hypertrophic scars than in normal skin. Conclusion It indicates that altered regula- tion of extracellular matrix components is an important factor for abnormal human wound healing. |
| Keywords: | Wound healing Fibronectin Hypertrophic scar Quantitative RT-PCR |
| 本文献已被 CNKI 等数据库收录！ | |