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| 辣椒素对银屑病小鼠模型的作用 | |
| 引用本文： | 张爱军,李兴华,王美纳,王冬云,张磐谏. 辣椒素对银屑病小鼠模型的作用[J]. 中国皮肤性病学杂志, 2004, 18(6): 333-335 |
| 作者姓名： | 张爱军 李兴华 王美纳 王冬云 张磐谏 |
| 作者单位： | 西安交通大学第二医院,陕西,西安,710004 |
| 基金项目： | 陕西省科技计划资助项目 [2 0 0 3K1 1 G7(3) ] |
| 摘 要： | 目的 研究辣椒素对银屑病小鼠模型的作用机制。方法 采用小鼠尾部鳞片表皮模型和阴道上皮细胞有丝分裂模型 ,观察辣椒素对表皮细胞分化及上皮细胞有丝分裂的影响。结果 辣椒素能促进小鼠尾部鳞片表皮颗粒层形成 (P <0 .0 1) ,显著抑制小鼠阴道上皮细胞的有丝分裂 (P <0 .0 1)。结论 辣椒素对银屑病小鼠模型的作用可能与促进表皮细胞正常分化和抑制表皮细胞增殖有关。 |
| 关 键 词： | 辣椒素 银屑病 模型小鼠 |
| 文章编号： | 1001-7089(2004)06-0333-03 |
| 修稿时间： | 2003-10-09 |
Effect of Capsaicin on Psoriasis Animal Model |
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| ZHANG Ai-jun,LI xing-hua,WANG Mei-na,et al. Effect of Capsaicin on Psoriasis Animal Model[J]. The Chinese Journal of Dermatovenereology, 2004, 18(6): 333-335 | |
| Authors: | ZHANG Ai-jun LI xing-hua WANG Mei-na et al |
| Abstract: | Objective To study the therapeutic mechanism of Capsaicin on psoriasis animal model.Methods The mouse tail scaled epidermis and the vaginal epithelial in estrus cycle were used to assess the effects of Capsaicin on epidermal keratinization and epithelial mitosis respectively.Results All of the density of Capsaicin solution revealed a significant promoting effects on the formation of granular layer in the tail scale epidermis(P<0.01)and a significant inhibiting effects on vaginal epithelial mitosis(P<0.01). Conclusion The effect of Capsaicin on psoriasis animal model may be related to promoting the formation of granular cells and inhibiting the proliferation of epidermic cells. |
| Keywords: | Capsaicin Psoriasis Animal Models |
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