云木香不同提取物对小鼠胃排空和小肠推进功能的影响

目的:研究云木香3种提取物对小鼠胃排空和小肠推进功能的影响,并探讨云木香影响胃肠道的物质基础.方法:采用改良的酚红含量测定法观察云木香3种提取液对正常状态下、新斯的明所致的亢进状态下、阿托品所致的抑制状态下小鼠胃排空和小肠推进功能的影响.结果:挥发油能够显著降低正常小鼠胃酚红排空率(P＜0.01),能够显著提高阿托品所致抑制状态下的小鼠胃酚红排空率(P＜0.01),能够显著降低新斯的明所致亢进状态下的小鼠胃酚红排空率(P＜0.01),并降低小肠酚红推进率(P＜0.05).结论:云木香挥发油能够抑制正常小鼠胃排空,改善阿托品所致抑制状态下的小鼠胃排空障碍,拮抗新斯的明所致的小鼠胃排空和小肠推进功能亢进.挥发油是云木香对小鼠胃肠道起作用的物质基础.

Effect of Yunmuxiang on Gastric Emptying and Intestinal Propulsion of Mice

Objective: To study the effect of 3 kinds of extract of Yunmuxiang on gastric emptying and intestinal propulsion of mice,and to find the material basis of Yunmuxiang which affact gastric emptying and intestinal propulsion of mice. Method: Using modified determination of content of phenol red to observe the effect of 3 kinds of extract of Yunmuxiang on gastric emptying and intestinal propulsion of mice in normal state, hyperthyroidism state caused by neostigmine, inhibiting state caused by atropine. Result: Volatile oil of Yunmuxiang could significant decrease gastric emptying rate of phenol red of normal mice(P<0.01),could significantly improve gastric emptying rate of phenol red in the state of inhibition caused by atropine(P<0.01),could significantly decrease gastric emptying rate of phenol red in the state of hyperthyroidism caused by neostigmine(P<0.05). Conclusion: The extract of Yunmuxiang can inhibit gastric emptying of normal mice,can improve gastric emptying of mice in the state of inhibition caused by atropine, antagonistise gastric emptying and intestinal propulsion of phenol red in the state of hyperthyroidism caused by neostigmine. Volatile oil and low-polar substances are more likely to the material basis of Yunmuxiang which affact gastrointestinal tract of mice.