经鼻胃镜检查的临床应用评估及对照研究

目的 探讨使用超细电子胃镜经鼻临床应用的安全性和价值.方法 将240例行胃镜检查的患者随机分成3组,分别为超细胃镜经鼻检查组(A组,n=82)、超细胃镜经口检查组(B组,n=79)及标准胃镜经口检查组(C组,n=79).在胃镜检查前及检查过程中通过监护仪记录患者的收缩压、舒张压、脉率、血氧饱和度、心肌耗氧量(以心率动脉收缩压乘积来衡量),并记录内镜插入时间和检查完成时间.胃镜检查结束后所有患者均完成一份问卷调查表.结果 在胃镜检查过程中,3组患者的血氧饱和度均有轻微的下降,但下降的比例各组间差异无统计学意义;A组患者收缩压、舒张压、脉率、心肌耗氧量增加的比例均显著低于B组和C组(P＜0.05).A组患者胃镜插入时不适感及检查时恶心程度的VAS评分最低(P＜0.05).经鼻胃镜检查较经口胃镜检查耗时更长(P＜0.05),但随着检查例数的增加.经鼻胃镜检查的插入时间会逐渐缩短.结论 经鼻胃镜检查,相对于普通内镜检查,患者的痛苦小,耐受性更好,对心血管功能的影响更小,是一种安全、易于掌握的胃镜检查方法,经鼻插入可能是超细胃镜最佳的进镜途径.

Evaluation of transnasal esophagogastroduodenoscopy:a controlled trial

Objective To evaluate the safety and efficacy of ultra-thin transnasal esophagogastroduodenoscopy(EGD).Methods The patients(n=240)receiving diagnostic EGD were randomly assigned to 3 groups to undergo ultra-thin trails-nasal EGD(group A,n=82),ultra-thin trans-oral EGD(group B,n=79)and conventional trans-oral EGD(group C,n=79).The blood pressure,pulse rate,arterial oxygen saturation,myocardial oxygen consumption were monitored and recorded before and during the procedure,as well as the operation time.All patients completed a questionnaire after the procedure.Results No significant difference was found in drop of arterial oxygen saturation between three groups.Increases in pulse rate,blood pressure,rate-pressure product in group A were significantly lower than those in group B and C(P＜0.05).Patients in group A experienced the lowest VAS scores of discomfort and nausea during the procedure (P＜0.05).But examination time and insertion time were significantly longer in group A than those in group B and C.With the increase in number of cases,the insertion time for group A decreased gradually.Conclusion Ultra-thin trans-nasal EGD is well tolerated and has fewer hemodynamic effects.It is safe and may be the optimal route of intubation with ultra-thin scopes.