非甾体类抗炎药和幽门螺杆菌与消化性溃疡发病关系的临床分析

目的分析非甾体类抗炎药(NSAIDs)、幽门螺杆菌(Hp)与消化性溃疡发病的关系。方法对溃疡组与对照组进行询问服用NSAIDs史,采用快速尿素酶试验检测是否感染Hp。应用病例对照研究的方法,进行统计学处理与分析,采用单因素分析及多因素分析的方法计算病例组和对照组暴露于NSAIDs和Hp这一事件的优势比(OR)来评价发生消化性溃疡的相对危险度。结果①服用NSAIDs的消化性溃疡OR值为2.225;②服用NSAIDs发生消化性溃疡并发上消化道出血的OR值为3.635;③服用NSAIDs发生胃溃疡的OR值为2.537;发生十二指肠溃疡的OR值为1.996;④单纯感染Hp的消化性溃疡患者OR值为6.85,单纯服用NSAIDs的消化性溃疡患者OR值为6.10,既服用NSAIDs,且感染Hp的消化性溃疡患者OR值为13.70。结论①服用NSAIDs发生消化性溃疡的机率较不服用NSAIDs的大;②服用NSAIDs发生消化性溃疡并发上消化道出血的风险高于不服用NSAIDs;③服用NSAIDs发生胃溃疡比发生十二指肠溃疡的机率高;④Hp感染者同时应用NSAIDs增加发生消化性溃疡的危险性。

Analysis of relationship between helicobacter pylori and non-steroidal anti-inflammatory drugs in peptic ulcer

Objective To analyze the relationship between helicobacter pylori and non-steroidal anti-inflammatory drugs(NSAIDs) in the patients with peptic ulcer.Methods The patients in peptic ulcers group were followed-up and asked whether they took NSAIDs and examined Hp.These two groups' OR value were calculated of the exposed factors(Hp infection and NSAIDs used) to evaluate the risk of peptic ulcer with mono-agent and multi-agent analysis.Results OR value was 2.225,3.635,2.537 and 1.996 in peptic ulcers,in peptic ulcers' complication hemorrhage,in gastric ulcers and in duodenal ulcers who took NSAIDs,respectively.OR value was 6.85 and 6.10 in peptic ulcers were infected by Hp and in peptic ulcers who took NSAIDs,respectively.OR value was 13.70 in peptic ulcers who took NSAIDs and Hp positive.Conclusion There are more risks in patients with peptic ulcers by taking NSAIDs,especially in patients with Hp infection and taking NSAIDs.