2型糖尿病合并高血压患者肾脏血流动力和功能变化

目的　探讨 2型糖尿病 (T2 DM )合并高血压 (EH)患者肾脏血流动力和功能的变化特点 ,为肾脏损害的防治提供理论依据。方法　 3 64例患者分为T2 DM组、EH组及T2 DM合并EH组 (DM +EH) ,对 3组患者的相关临床资料及肾脏多普勒等检查结果进行对比分析。结果　DM +EH组与单纯DM或EH组的肾动脉血流速度及肾动脉阻力指数比较差异有统计学意义 ,P <0 0 1。DM、EH、DM +EH组的 2 4h尿微量蛋白定量 3组间两两比较差异有统计学意义 ,P <0 0 1。DM +EH组与单纯EH组肾功能比较差异有统计学意义 ,P <0 0 1。DM +EH组患者肾功能不全发生率明显升高。结论　T2 DM、EH及T2 DM +EH组肾脏血流动力和功能变化明显不同 ,糖尿病合并高血压能明显加重患者肾脏血流动力和功能损害

Clinical characteristics of kidney structure and function in patients with hypertensive diabetes mellitus

Objective: To investigate the characteristics of kidney structure and function in T_2DM patients with hypertension and provide a clinical bases for prevention of kidney dysfunction. Methods: 364 patients were divied into T_2DM (n=106), essential hypertension (EH, n=136), and hypertensive DM (n=122). Color Doppler echocardiogram was measured in all the patients. Results: Blood speed(VS )and resistance index (RI) in hypertensive DM were significantly increased compared with EH and T_2DM (P<0.01). 24 h protein of urine was significantly increased compared in EH and DM and hypertensive DM (P<0.01). SPS was significantly increased compared in EH and DM and hypertensive DM (P<0.01). Conclusion: Changes in kidney structure and function among T_2DM, EH and hypertensive DM were markedly different. High blood pressure will injure the kidney structure and function in hypertensive DM.