| 黄嘌呤-黄嘌呤氧化酶对培养心肌细胞的损伤及硒的保护作用 |
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| 引用本文： | 王雪青,江岩,董力.黄嘌呤-黄嘌呤氧化酶对培养心肌细胞的损伤及硒的保护作用[J].中国病理生理杂志,1991(3). |
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| 作者姓名： | 王雪青 江岩 董力 |
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| 作者单位： | 河北医科院病生室
(王雪青，江岩)，河北医科院病生室(董力) |
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| 摘 要： | 向培养心肌细胞中加入黄嘌呤-黄嘌呤氧化酶(X-XOD)后,动作电位的APA、OS、V_(max)及APD减少,MDP、TP水平上移;细胞在MEM中搏动率降低,加钡后细胞收缩频率迅速增加,且X-XOD作用时间越长,上述改变越显著。X-Mo的作用与此类似,但较轻。加硒则能逆转上述的细胞损伤性变化。这表明X-XOD和X-Mo均能造成心肌细胞损伤,硒对心肌细胞有保护作用。
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| 关 键 词： | 细胞 培养的 游离基类 硒 动作电位 膜 |
The damadge of cultured myocytes by xanthine-xanthine oxidase and the reversed effect of Se |
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| Wang Xeu-Qing,Jiang Yan,et al.The damadge of cultured myocytes by xanthine-xanthine oxidase and the reversed effect of Se[J].Chinese Journal of Pathophysiology,1991(3). |
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| Authors: | Wang Xeu-Qing Jiang Yan |
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| Institution: | Wang Xeu-Qing,Jiang Yan,et al Department of Pathophysiology,hebei Academy of Medical Sciences,Shijiazhuang |
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| Abstract: | When cultured heart cells were exposed to X-XOD containing medium, the absolute values of APA, OS, Vmax, APD, MDP, TP decreased; the percentage of beating clusters reduced in single MEM medium, but the frequency increased sharply in Ba containing medium. The longer the period exposed to X-XOD, the more significant are the variations of the electrical and contractile indices. The effects of X-Mo was similar to that of X-XOD, but to a slightly less extent. Se significantly converted all the indices. It is concluded that X-XOD can induce serious injury of cultured myocytes, and so does the X-Mo, while Se can protect the cells from the injury. |
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| Keywords: | Cells cultured Free radicals Selenium Action potential Membranes |
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