利培酮口服液治疗老年期痴呆患者病理性行为对照研究

目的：对具有病理性行为的老年期痴呆患者分别给予利培酮和氟哌啶醇治疗的疗效进行比较。方法：65例伴有病理性行为的老年期痴呆患者随机分为研究组33例和对照组32例,分别给予利培酮口服液和氟哌啶醇针剂治疗。疗程2周。于治疗前及治疗2h、24h、72h、1周和2周采用痴呆病理行为评定量表（BEHAVE-AD）和治疗中出现的症状量表（TESS）评定疗效及不良反应,并观察服药依从性。结果：利培酮口服液与氟哌啶醇针剂疗效相仿（P〉0.05）,但利培酮不良反应更小,依从性更好（P〈0.05或P〈0.01）。结论：利培酮口服液更适用于老年期痴呆患者的病理性行为的治疗。

A control study on risperidone oral solution in the treatment of psychiatric symptoms of senile dementia patients

Objective：To compare the efficacy of risperidone oral solution and haloperidol injection in the treatment of psychiatric symptoms of senile dementia（SD） patients.Method：Sixty-five patients with SD and psychiatric symptoms were randomized to receive a flexible dose of either haloperidol injection or risperidone oral solution for a period of 2 weeks.Psychiatric symptoms of SD were assessed with behavioral pathology in Alzheimer＇s disease rating scale（BEHAVE-AD）and treatment emergent symptom scale （TESS）.Scales were rated at baseline and 2nd h,24th h,72nd h,1st week,2nd week during treatment.Results：There was no significant difference in both of the group（P〈0.05）.The risperidone oral solution group showed less side effects and has better compliance （P〈0.05或P〈0.01）.Conclusion：Both haloperidol and risperidone could improve psychiatric symptoms of SD.The tolerability of risperidone was better than haloperidol.