医院感染铜绿假单胞菌的耐药性调查

目的：探讨医院感染铜绿假单胞菌（PAE）的耐药现状,为临床医师合理使用抗生素提供科学依据。方法：严格按照《全国临床检验操作规程》进行细菌培养和鉴定菌株;采用KB法进行药敏试验。结果：212株PAE中,泛耐药菌株检出率为14.6%。药敏试验结果表明：PAE对亚胺培南、美罗培南、哌啦西林/他唑巴坦、头孢哌酮/舒巴坦耐药率最低（14.2%～21.7%）,对其他常用抗菌药物的耐药率均〉40%。结论：我院铜绿假单胞菌耐药性已非常严重,应加强合理使用抗生素管理工作,遏制多药耐药细菌导致的医院感染暴发流行。

Investigation on antimicrobial resistance of pseudomonas aeruginosa in nosocomial infections

Objective：To investigate antimicrobial resistance of pseudomonas aeruginosa（PAE）in nosocomial infections and provide the scientific evidence for clinically reasonable choice of the antibiotics.Method：Referring to national guide to clinical laboratory operation procedures,the strains were cultured and identified.The susceptibility testing was performed by K-B methods.Result：14.6% pan-resistant strains were found in 212 isolates of PAE.The resistance rates of imipenem,meropenem,piperacillin/tazobactam and cefoperazone/sulbactam varied from 14.2% to 21.7%.Those of the other antibiotics were all above 40%.Conclusion：The antimicrobial resistance of PAE in our hospital was increasingly serious.We should strengthen antibiotic management and prevent the outbreak and prevalence of multiresistant strains in nosocomial infections.