TTV在黑龙江省不明原因肝炎患者中的比例及其致病性

目的 研究一种肝炎病毒(输血传播病毒，TTV)在黑龙江省不明原因肝炎患者中的比例、疾病的发展过程及健康人的携带情况，以探讨输血传播病毒的致病性。方法 采用半套式—聚合酶链反应(seeni—nested PCR)方法对不明原因性肝炎患者，包括45例急性肝炎、27例慢性肝炎、8例重型肝炎，11例健康志愿献血员进行TTV的定性检测。对9例经过第一步检测TTV—DNA阳性的急性恢复期患者行再次检测。结果 80份不明原因性肝炎患者血清中15份TTV阳性，占18．75％。其中急性肝炎患者血清中检出9份TTV阳性，占20％;慢性肝炎患者血清中检出5份TTV阳性，占18．52％；8份重型肝炎中检出1份TTV阳性，占12．5％。其中9份TTV阳性的急性不明原因性肝炎患者在恢复期采集的第2份血清TTV检测结果均为阴性.11份健康志愿献血员的血清中没有检出TTV—DNA。结论 输血传播病毒具有致病性。可以引起急性、慢性、重型肝炎，临床表现与甲—戊型肝炎的临床表现没有明显区别。急性TTV病毒性肝炎可以痊愈。TTV存在输血以外的传播途径。

Rate and pathogenicity of TTV in liver diseases of unknow etiology in Hei Long-jiang province

Objective To study the distribution and pathogenicity of transfusion transmitted virus(TTV) in liver diseases of unknown etiology and the infection rates of TTV in healthy person in Hei Long jiang province.Methods TTV was detected by semi nested polymerase chain reaction (PCR) in 80 patients with liver diseases of unknown etiology,11 healthy blood donors and 9 convalescent patients of TTV positive with acute liver diseases. Results TTV positive rates was 18.75%(15/80) in liver disease of unknown etiology. TTV positive rates were 20.00% (9/45), 18.52% (5/27), 12.50% (1/8) in acute, chronic and fulminant liver diseases with unknown etiology, respectively. TTV was negative in convalescent serum of TTV positive patients with acute liver diseases and 11 healthy blood donors.Conclusion TTV has pathogenicity. TTV can cause acute, chronic or fulminant hepatitis, and clinical findings cannot be distinguished from those of hepatitis A to G. Acute TTV hepatitis can complete recovery. TTV may have non transfusion transmitting pathway.