| 雌激素孕激素及促性腺激素对卵巢癌细胞株H0-8910体外生长的调控 |
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| 引用本文： | 陈红,胡琢英,邓晓谷. 雌激素孕激素及促性腺激素对卵巢癌细胞株H0-8910体外生长的调控[J]. 中山大学学报(医学科学版), 2001, 22(1): 29-32 |
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| 作者姓名： | 陈红 胡琢英 邓晓谷 |
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| 作者单位： | 1. 深圳宝安区人民医院妇产科,
2. 重庆医科大学 附属第一医院妇产科, |
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| 摘 要： | 【目的】探讨雌激素(E2)、孕激素(P)及促性腺激素(FSH)对卵巢癌细胞株体外生长的调控。【方法】采用四甲基偶氮唑蓝(MTT)比色法比较细胞数目，用流式细胞仪检测细胞周期。【结果】10
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| 关 键 词： | 卵巢肿瘤/药物疗法； 雌激素/药理学； 孕激素/药理学；促性 腺激素/药理学； 激素/治疗应用 |
| 文章编号： | 1000-257 X(2001)01-0029-04 |
| 修稿时间： | 2000-06-15 |
Study of the RegulatoryEffects of Estrogen Progesterone and Gona dotropins on Growth of Ovarian Cancer Cell LineH0-8910 in Vitro |
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| CHEN Hong,HU Zuo-Ying,DENG Xiao-gu. Study of the RegulatoryEffects of Estrogen Progesterone and Gona dotropins on Growth of Ovarian Cancer Cell LineH0-8910 in Vitro[J]. Journal of Sun Yatsen University(Medical Sciences), 2001, 22(1): 29-32 |
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| Authors: | CHEN Hong HU Zuo-Ying DENG Xiao-gu |
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| Affiliation: | CHEN Hong 1,HU Zuo-ying 2,DENG Xiao-gu 2 |
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| Abstract: | 【Objective】 The study was carried out to investigate t he effects of estradiol(E2), follicle-stimulating hormone(FSH) and progestero ne(P) on the proliferation of ovarian cancer cell line H0-8910 in vitro. 【 Method】 Cultivating human ovarian serous cystadenocarcinoma cell line H0-8910 in vitro, comparing cell numbers using MTT method, flow cytometry detecting cell cycle. 【Results】 After incubation with 10-12 mol/L E2 or 10 μg/L FSH for 48 hours, cell proliferation increased significantly. E2 and FSH increased th e cells percentage in Sphase and G2/M phase of cell cycle respectively P could inhibit H0-8910 cells growth significantly in a dose-dependent manner. 【Conc lusion】 It is suggested that E2 and FSH can stimulate the proliferation of ov arian cancer cell, P can inhibit cell growth. |
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| Keywords: | ovarian neoplasm/drug therapy estrogen/pharmacology progesterone/pharmacology gonadotropins/pharmacology hormones/therapeutic use |
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