3种硬化治疗在口腔颌面部静脉畸形中的应用

目的探讨单纯使用平阳霉素、单纯使用无水乙醇及无水乙醇结合平阳霉素对口腔颌面部静脉畸形硬化治疗的疗效。方法 266例口腔颌面部静脉畸形患者随机分成3组：A组90例,使用平阳霉素注射;B组89例,使用无水乙醇注射;C组87例,先向病灶内注射无水乙醇,待病灶缩小后再注射平阳霉素。比较3组的疗效和并发症。结果随访12～24个月,A组有效率为78.9%,B组为100%,C组为97.7%,经卡方检验,A组与B组间的有效率差异有统计学意义（χ2=21.01,P〈0.01）;A组与C组间的有效率差异有统计学意义（χ2=14.96,P〈0.01）;B组与C组间的有效率差异无统计学意义（χ2=2.07,P〉0.05）。A、B、C组组织坏死的发生率分别为4.4%、52.8%和9.1%。比较3组间组织坏死发生率,A组与B组间差异有统计学意义（χ2=51.48,P〈0.01）;A组与C组间差异无统计学意义（χ2=1.56,P〉0.05）;C组的组织坏死发生率明显低于B组,差异有统计学意义（χ2=39.14,P〈0.01）。结论使用无水乙醇结合平阳霉素对口腔颌面部静脉畸形进行硬化治疗具有疗程短、平阳霉素用量少、并发症轻等优点,其疗效均优于2种硬化剂单独使用。

Clinical Comparison of Three Sclerotherapy to Venous Malformations in Oral and Maxillofacial Region

Objective This study is to compare the efficacy of sclerotherapy of ethanol,pingyangmycin and the combination of ethanol and pingyangmycin to venous malformations in the oral and maxillofacial region.Methods Three hundred and fifty-two patients suffering from venous malformations of oral and maxillofacial region were selected as candidates of this study.The enrolled 266 patients were divided into 3 groups randomly.Group A(n=90)was treated with pingyangmycin intralesional injection only,and Group B(n=89)was ...