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Education Modulates the Impact of White Matter Lesions on the Risk of Mild Cognitive Impairment and Dementia
Affiliation:1. Inserm, U1061, La Colombière Hospital, Montpellier, France;2. University of Montpellier 1, Montpellier, France;3. Montpellier University Hospital, University Department of Adult Psychiatry, La Colombière Hospital, CHU de Montpellier, Montpellier, France;4. Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY;5. Department of Epidemiology and Public Health, University College London, United Kingdom;6. CHRU Montpellier, Montpellier, France;7. Monash Alfred Psychiatry Research Centre, The Alfred & Monash University Central Clinical School, Melbourne, Australia;6. Centre for Mental Health Research, Australian National University, Canberra, Australia;8. Faculty of Medicine, Imperial College, St Mary''s Hospital, London, United Kingdom;1. Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People''s Republic of China;2. Department of Clinical Epidemiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, People''s Republic of China;3. Department of Neurology, Huashan Hospital, Fudan University, Shanghai, People''s Republic of China;4. Department of Neurology, The First Affiliated Hospital of Xi''an Jiaotong University, Xi''an, People''s Republic of China;5. Department of Psychiatry, The First Hospital, Huaxi Medical College, Chengdu, People''s Republic of China;6. Department of Neurology, Beijing Sixth Hospital, Beijing, People''s Republic of China;7. Department of Epidemiology and Biostatistics, Institute of Basic Medicine Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, People''s Republic of China;8. Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA;1. Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA;2. G.H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA;3. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;4. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;5. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA;6. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA;7. Inserm, 1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France;8. Faculty of Medicine University of Montpellier 1, Montpellier, France;9. Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College, University College London, London, UK;1. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;2. Taub Institute for Research on Alzheimer''s disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA;3. The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA;4. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA;5. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA;1. Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan;2. Department of Innovative Dementia Prevention, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;3. Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan;4. Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan;5. Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;1. Cognitive Neuroscience Division, The Taub Institute for Research on Aging and Alzheimer''s Disease, Columbia University, New York, NY, USA;2. Departamento de Psiquiatria e Saúde Mental, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal;3. Mental Health Data Science, New York State Psychiatric Institute, New York, NY, USA;4. Department of Biostatistics, Columbia University, New York, NY, USA;5. Department of Biostatistics and Psychiatry, Columbia University, New York, NY, USA;1. Taub Institute for Research on Alzheimer''s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA;2. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA;3. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;4. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA;5. Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Abstract:
Keywords:Alzheimer disease  dementia  mild cognitive impairment  white matter lesions  magnetic resonance imaging  cognitive reserve  cohort studies
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