Sequential emergence of colistin and rifampicin resistance in an OXA-72- producing outbreak strain of Acinetobacter baumannii |
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| Authors: | Anaïs Potron Maxime Bour Pauline Triponney Joris Muller Christelle Koebel Rémy A. Bonnin Patrick Plésiat |
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| Affiliation: | 1. Centre National de Référence de la résistance aux antibiotiques, Centre Hospitalier Universitaire de Besançon, France;2. UMR6249 CNRS Chrono-Environnement, Université de Franche-Comté, Besançon, France;3. Laboratoire d''Hygiène, Centre Hospitalier Universitaire de Strasbourg, France;4. Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Strasbourg, France;5. EA7361 ‘Structure, dynamique, fonction et expression des β-lactamases à large spectre’, Université Paris-Sud, LabEx Lermit, Faculté de Médecine, Le Kremlin-Bicêtre, France;6. Centre National de Référence de la résistance aux antibiotiques, laboratoire associé, Le Kremlin-Bicêtre, France |
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| Abstract: | ObjectivesThis study reported a hospital outbreak due to an extensively drug-resistant (XDR) OXA-72-producing strain of Acinetobacter baumannii (A. baumannii).Methods and ResultsThe isolates were found to be genotypically indistinguishable by whole-genome multiple locus sequence typing, and to belong to the international clonal complex CC2. One of these isolates sequentially developed a high resistance to colistin and rifampicin under treatment, as a result of mutations in genes pmrB and rpoB, respectively. The blaOXA-72 gene was localised on a 10-kb transferable plasmid, named pAB-STR-1, whose sequence is nearly identical to that of another plasmid previously found in Lithuanian strains, pAB120.ConclusionThis report highlighted the need to carefully monitor the emergence of colistin and rifampicin resistance in patients treated for infections with multidrug-resistant A. baumannii. |
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| Keywords: | Outbreak Colistin resistance Rifampicin resistance Carbapenemase |
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