还原性谷胱甘肽对肺癌放射治疗患者的保护作用

目的：了解还原性谷胱甘肽在老年非小细胞肺癌（NSCLC）患者放射治疗中的保护作用。方法：采用临床对照试验，比较还原性谷胱甘肽和安慰剂运用对2组放疗患者不良反应的发生有无差异。结果：白细胞下降率试验组为14．2％，对照为47．6％，有显著性差异（P＜0．05）；放射性食管炎发生率2组亦有显著性差异（P＜0．05）；放射性肺炎发生率2组相比无显著性差异；显效率亦无显著性差异。结论：还原性谷胱甘肽在老年非小细胞肺癌虱放射治疗中白细胞的下降和放射性食管炎的发生有保护作用，并且不影响放疗的效果。

The protection of glutathione in the elderly patients with hmg cancer undergoing radiotherapy

Objective To study the protective effert glutathione in elderly patients with non small cell lung cancer undergoing radiotherapy. Methods Clinical contrl trial was applied to determine the different adverse reaction between glutathione and placebo in the elderly patients undergoing radiotherapy. Results The decreasing rate of white blood cell was 14 2% in trials and 47 6% in controls,which was remarkably different ( P <0 05)before the two groups;the incidence of radiation esophagitis between two groups was remarkably different too ( P <0 05);the incidence of radiative pneumonia between two groups was not significantly different( P >0 05);the effective rate was not significantly different( P >0 05) either. Conclusions Glutathione can lower the decreasing rate of white blood cell and the incidence of radiative esophagitis in elderly patients with non small cell lung cancer undergoing radiotheraphy,but do not affect the effective rate of radiotheraphy.