艾司西酞普兰与西酞普兰治疗抑郁症的随机、双盲对照研究

目的观察艾司西酞普兰治疗抑郁症的疗效及安全性。方法将符合CCMD-3诊断标准的48例抑郁症患者随机分为2组,试验组用艾司西酞普兰治疗,对照组用西酞普兰治疗,疗程6周。在治疗前及治疗1、2、4、6周末用汉密尔顿抑郁量表（HAMD）各评定1次。结果6周末试验组和对照组的HAMD总分分别从（21．36±2．69）、（20．78±2．43）减到（6．76±3．10）、（6．91±4．70）,有效率分别为84．0％、82．6％,痊愈率为52．0％、47．8％,2组间总体疗效相当（P〉0．05）。但在1周末时试验组比对照组的HAMD减分及减分率明显增加,2组间差异有显著性（P〈0．05）。2组间不良反应较轻,无显著性差异（P〉0．05）。结论国产艾司西酞普兰是一种安全有效的抗抑郁药。

Escitalopram vs citalopram for depression:a randomized, double-blind, double-dummy, multicenter, parallel controlled study

Objective To evaluate the efficacy and safety of domestic escitalopram for depressive patients. Methods Forty eight patients meeting CCMD-3 criteria of depressive episode were randomized into an escitalopram group （n= 25） and a citalopram group （n=23） for a 6 week double-blind, double-dummy controlled study with flexible dosages. The HAMD-17, CGI, adverse event rating scale and related laboratory examinations were used to assess the effectiveness and safety of the treatment by the end of 1, 2, 4, and 6 weeks. Results After 6 weeks of treatment, the HAMD scores decreased from （21.36±2.69） and （20.78±2.43） to （6.76±3.10） and （6.91±4. 70） in the escitalopram group and the citalopram group respectively, the effective rate was 84. 0% and 82. 6%, and the curative rate was 52.0% and 47.8%. There was no significant difference between the 2 groups （P〉0.05） . There was no significant difference in the effective and curative rate between the 2 groups （P〉0.05）. At the end of the first week, reducing scores and reducing scores rate of HAMD scores in the eseitalopram group were higher than those of the control group （P〈0.05）. The main side effects had no significant difference between the 2 groups （P〉0.05）. Conclusion Domestic escitalopram is an effective and safe antidepressant.