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| Expression of Bcl-2 and Survivin in uterine cervical carcinogenesis and correlation between the expression and infection of HPV_(16/18) | |
| 引用本文： | FU XI ZHAO~1,YA QIN MU~1,JUN CHENG GUO~1 and RUN HUA LIU~2~1 Microbiological Lab, ~2Surgery Lab,Medical College of Datong University,Datong,P. R. China. Expression of Bcl-2 and Survivin in uterine cervical carcinogenesis and correlation between the expression and infection of HPV_(16/18)[J]. 中华微生物学和免疫学杂志(英文版), 2005, 3(4): 246-253 |
| 作者姓名： | FU XI ZHAO~1 YA QIN MU~1 JUN CHENG GUO~1 and RUN HUA LIU~2~1 Microbiological Lab ~2Surgery Lab Medical College of Datong University Datong P. R. China |
| 作者单位： | FU XI ZHAO~1，YA QIN MU~1，JUN CHENG GUO~1 and RUN HUA LIU~2~1 Microbiological Lab; ~2Surgery Lab，Medical College of Datong University，Datong，P. R. China |
| 摘 要： | Carcinomaofthecervixisthesecondleading causeofdeathamongwomenworldwide.Each year,anestimated500000casesarenewlydiag nosed[1].Manystudiesshowedinfectionofhu manpapillomavirus(HPV)wasoneofthemost importantetiologicfactorsforcervicalcarcinoma[24].Morethan95%ofallcervicalcarcinomas havebeenfoundtobeassociatedwithHPV(ma inlytypes16and18)[5].Thestudiesinmolec ularoncologyrecentlyshowedthatitresultedin occurrenceanddevelopmentofcervicalcarcinomasthatcarcinogenicfactorsmadeproto oncogene activatean… |
| 关 键 词： | 子宫癌 基因表达 HPV16 HPV18 乳头状病毒 |
Expression of Bcl-2 and Survivin in uterine cervical carcinogenesis and correlation between the expression and infection of HPV16/18 |
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| FU XI ZHAO YA QIN MU JUN CHENG GUO RUN HUA LIU. Expression of Bcl-2 and Survivin in uterine cervical carcinogenesis and correlation between the expression and infection of HPV16/18[J]. Chinese Journal of Microbiology and Immunology, 2005, 3(4): 246-253 | |
| Authors: | FU XI ZHAO YA QIN MU JUN CHENG GUO RUN HUA LIU |
| Affiliation: | [1]Microbtological Lab [2]Surgery Lab, Medical College of Datong University, Datong , P. R. China |
| Abstract: | To investigate the expression of Bcl-2 and Survivin and HPV_ 16/18 infection in uterine cervical carcinogenesis, formalin-fixed, paraffin-embedded specimens from cervical carcinomas, cervical intraepithelial neoplasia (CIN) and normal cervical tissues were studied. Using streptavidin-biotin peroxidase (S-P) immunohistochemical technique, the authors examined the expression of Bcl-2 and Survivin in these specimens. The number of apoptosis cells was assessed in situ by TdT-mediated dUTP-biotin end labeling (TUNEL) method. The infection of HPV type 16, 18 DNA were determined by PCR. It was found that there were significant differences in Bcl-2, Survivin and apoptotic index (AI) between cervical carcinomas, CIN and normal cervical tissues, respectively. Expression of Bcl-2 and AI were correlated with tumor grades, clinical stages and lymph node metastasis and expression of Survivin was associated with tumor grades and lymph node metastasis. There were different positive rate of HPV_ 16/18 between cervical carcinomas, CIN and normal tissues and were not associated with tumor grades, clinical stages and lymph node metastasis. The infection of HPV_ 16/18 was associated with the expression of Bcl-2, Survivin and AI, respectively. It was concluded that the abnormal expression of Bcl-2, Survivin and infection of HPV_ 16/18 were associated with cervical carcinomas. They possibly can be useful indexes for the primary screening and prognosis of cervical carcinomas. |
| Keywords: | Bcl-2 Survivin Apoptosis Human papillomavirus Cervical carcinomas |
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