Gut microbiota profiling in hematopoietic stem cell transplant recipients: Towards personalized medicine |
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| Authors: | J.S. Gill S.P. Singh Sanjeevan Sharma Ashwini Agarwal |
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| Affiliation: | 1. Associate Professor, Department of Microbiology, Armed Forces Medical College, Pune 411040, India;2. Senior Adviser (Microbiology), Command Hospital (Southern Command), Pune 411040, India;3. Classified Specialist (Medicine & Hematology), Command Hospital (Southern Command), Pune 411040, India;4. Professor, Department of Microbiology, Armed Forces Medical College, Pune 411040, India;1. Graded Specialist (Anaesthesia), 356 Field Hospital, C/o 99 APO, India;2. Graded Specialist (Anaesthesia), INHS Jeevanti, Goa, India;1. Classified Specialist (Surgery) and Pediatric Surgeon, Command Hospital (Southern Command), Pune, 411040, India;2. Senior Advisor (Surgery) and Pediatric Surgeon, Command Hospital (Southern Command), Pune, 411040, India;3. Resident, Department of Surgery, Armed Forces Medical College, Pune, 411040, India;4. Senior Advisor (Surgery) and Pediatric Surgeon, Army Hospital (R&R), Delhi Cantt, 110010, India;1. Senior Adviser (Anaesthesia), Command Hospital (Eastern Command), Kolkata, India;2. ACIDS Med, HQ IDS (Med), Integrated Headquarters of MOD, New Delhi, India;3. CSO, HQ Andaman & Nicobar Command, C/o Navy Office, Port Blair, India;4. Anesthesiologist, Military Hospital Shimla, India;1. Graded Specialist (ENT), Military Hospital, Yol Cantt, Himachal Pradesh, India;2. HoD & Senior Advisor (ENT), Army Hospital (R&R), Delhi Cantt, India;3. Clinical Audiologist & Speech Therapist, Command Hospital (Air Force), Bengaluru, India;1. Associate Professor (Medicine & Pumonology), Command Hospital (Air Force), Bengaluru, India;2. Professor and Consultant (Medicine &Pulmonology), Command Hospital (Air Force), Bengaluru, India |
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| Abstract: | ![]()
BackgroundAntibiotic resistance in bacteria is a cause for concern, especially in hematopoietic stem cell transplant (HSCT) patients. Endogenous bowel microflora in HSCT patients get replaced by hospital multidrug resistant flora and pose risk of serious bacterial infection during the pre-engraftment stage. For decades, many methods to reduce the translocation of gut microbiota in HSCT patients have been attempted. Despite the logic, of using prophylactic antibiotics, there is no consensus on standard regimen. Personalized antibiotic prophylaxis-based on gut microbiota and clinical profile has been suggested by researchers. In this study, gut microbiota in HSCT recipients has been studied with antimicrobial susceptibility testing and detection of various antibiotic resistance phenotypes.MethodsSeventy-six HSCT patients (2016–2018) were included. Stool surveillance cultures and antibiotic susceptibility testing were performed. Bacterial isolates were classified into various antibiotic resistance phenotypes.ResultsThis study revealed that 73.75% HSCT recipients had gut colonized with antibiotic resistance microbiota which included extended-spectrum β-lactamase-, multidrug- and extensively drug-resistant phenotypes.ConclusionThis study reiterates the importance of individual profiling of gut microbiota in HSCT patients. |
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| Keywords: | Microbiota Transplant Extendedspectrum b-lactamase Multidrug-resistant Pandrug resistant |
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