B-cell neoplasms and Hodgkin lymphoma in the spleen |
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| Authors: | Julia T Geyer Sonam Prakash Attilio Orazi |
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| Affiliation: | 1. Weill Cornell Medicine, Department of Pathology and Laboratory Medicine, 525 E 68th Street, Starr Pavilion 715, New York, NY 10065, United States;2. University of California San Francisco, Department of Laboratory Medicine, Box 0100, Parnassus Avenue, Room 569C, San Francisco, CA 94143, United States;3. Texas Tech University Health Sciences Center, PL Foster School of Medicine, Department of Pathology, MSC 41022, 5001 El Paso Drive, El Paso, TX 79905, United States;1. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR;2. Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR;1. Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific St, Box 357470, Seattle, WA, United States;2. Department of Pathology, University of Virginia, 1215 Lee Street, Box 800214, Charlottesville, VA, United States |
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| Abstract: | ![]()
B-cell lymphoma of spleen may be primary (most commonly splenic diffuse large B-cell lymphoma) or secondary (typically low-grade non-Hodgkin lymphoma). Depending on the specific lymphoma subtype, there may be a predominantly white pulp pattern of involvement, a predominantly red pulp pattern or a focal nodular pattern. Splenectomy is the ideal specimen for a multiparametric integrative diagnosis of splenic lymphoma, as it allows for a combined study of morphology, immunohistology, flow cytometry, cytogenetics, and molecular genetic techniques. This review article describes the clinicopathologic characteristics of all the relevant B-cell neoplasms that may be encountered in a splenic biopsy or a splenectomy specimen. |
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