类风湿关节炎患者血清白细胞介素-4水平与间质性肺疾病的关系

目的明确类风湿关节炎(rheumatoid arthritis,RA)患者血清中白细胞介素-4(interleukin-4,IL-4)的水平及其与RA继发间质性肺疾病(interstitial lung disease,ILD)的关系,探讨RA及RA继发ILD的发病机制及相关因素。方法选择RA患者62例,其中单纯RA患者31例,RA伴发ILD患者31例;健康对照者30例。应用酶联免疫吸附(ELISA)法检测各组血清中IL-4水平,同时比较各组实验室指标免疫球蛋白(Ig)G、IgA、IgM、γ-球蛋白、类风湿因子(RF)、红细胞沉降率(ESR)、C反应蛋白(CRP)及关节肿痛数的差异,并进行相关性分析。结果 RA组血清IL-4水平为(61.87±41.36)pg/ml,健康对照组血清IL-4水平为(25.48±14.28)pg/ml,两组相比较差异有统计学意义(P<0.05);RA继发ILD组血清IL-4水平(92.70±32.01)pg/ml较单纯RA组(30.05±24.45)pg/ml明显升高,差异有统计学意义(P<0.05)。总RA组血清IL-4水平较健康对照组明显升高,差异有统计学意义(P<0.05);RA继发ILD组血清IL-4水平较单纯RA组明显升高,差异有统计学意义(P<0.05)。结论 IL-4可能参与RA的发病,且在RA并发ILD的发生发展中起一定作用。

Relationship between the Level of Interleukin- 4 Expression in Serum of Rheumatoid Arthritis Patients with Interstitial Lung Disease

Objective To investigate the action and correlation of interleukin- 4 （ IL- 4） with the pathogenesis of rheumatoid arthritis （RA）and rheumatoid arthritis related interstitial lung diseases （ILD）. Methods Sixty-two patients with RA were divided into two groups, 31 cases with simple RA group and 31 RA patients complicated with ILD （ RA ＋ ILD group）. Another 30 healthy subjects were included as the control group. Enzyme linked immunosorbent assay （ELISA） was used to detect the serum levels of IL-4 in 62 patients with RA （31 cases with simple RA and 31 cases with ILD ） and 30 healthy controls, laboratory indexes including IgG, lgA, IgM, γ-globlin （ γG ）, rheumatoid factor （ RF ）, erythrocyte sedimentation rate （ ESR）, C reactive protein（CRP） as well as the number of tender joints were compared in each group and all data were processed to carry out the relevance analysis. Results The level of IL-4 in patients with RA （61.87 ±41.36）pg/ml was significantly higher than that of the control group（25.48± 14. 28）pg/ml（P 〈 0.05 ）, while the IL-4 level of the RA ＋ ILD group（92. 70 ± 32. 01 ） pg/ml was significantly higher than that of the simple RA group （30. 05±24. 45 ） pg/ml （ P 〈 0. 05 ）. Conclusion IL-4 may play an important role in the pathogenesis of RA, and may contribute to the progression of lung fibrosis in RA patients.