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| 蛋白4.1R基因敲除小鼠的引种及繁殖 | |
| 引用本文： | 周晴晴,闫红霞,孙蕾,刘喜龙,李黎,汲翔,高艳锋,汲振余,祁元明,康巧珍.蛋白4.1R基因敲除小鼠的引种及繁殖[J].郑州大学学报(医学版),2011,46(2):179-182. |
| 作者姓名： | 周晴晴 闫红霞 孙蕾 刘喜龙 李黎 汲翔 高艳锋 汲振余 祁元明 康巧珍 |
| 作者单位： | 1. 郑州大学生物工程系,郑州,450001 2. 郑州大学基础医学院,郑州,450001 3. 河南省医药科学研究院,郑州,450052 |
| 基金项目： | 国家自然科学基金资助项目30972707,30873002; 河南省科技创新杰出青年基金资助项目104100510004 |
| 摘 要： | 目的:引种、繁殖4.1R基因敲除小鼠,用于蛋白4.1R功能的研究.方法:按照国家进出境动物检验检疫的具体要求,对引种自美国的3对4.1R基因敲除小鼠进行隔离、检疫.引进的种鼠按照SPF动物饲养标准操作规程在IVC屏障系统中进行1雄1雌长期同居方式繁殖,C57BL/6J对照组小鼠采用同样方式饲养繁殖.定期观察记录种鼠的繁... |
| 关 键 词： | 基因敲除小鼠 蛋白4.1R |
Introducing and breeding of protein 4.1R gene knock out mice |
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| ZHOU Qingqing , YAN Hongxia , SUN Lei , LIU Xilong , LI Li , JI Xiang , GAO Yanfeng , JI Zhenyu , QI Yuanming , KANG Qiaozhen.Introducing and breeding of protein 4.1R gene knock out mice[J].Journal of Zhengzhou University: Med Sci,2011,46(2):179-182. | |
| Authors: | ZHOU Qingqing YAN Hongxia SUN Lei LIU Xilong LI Li JI Xiang GAO Yanfeng JI Zhenyu QI Yuanming KANG Qiaozhen |
| Institution: | ZHOU Qingqing1),YAN Hongxia1),SUN Lei1),LIU Xilong1),LI Li1),JI Xiang2),GAO Yanfeng1),JI Zhenyu3),QI Yuanming1),KANG Qiaozhen1) 1)Department of Bioengineering,Zhengzhou University,Zhengzhou 450001 2)College of Basic Medical Sciences,Zhengzhou 450001 3)Henan Academy of Medical and Pharmaceutical Sciences,Zhengzhou 450052 |
| Abstract: | Aim:To introduce and reproduce 4.1R gene knock out mouse for exploring the functions of protien 4.1R.Methods:A total of 3 pairs of 4.1R gene knock out mice introduced from the USA were isolated and inspected according to the Animal Inspection and Quarantine Law of PR China.The introduced 4.1R knock out mice were breeding in IVC equipment according to the SPF Laboratory Animal Standard Operation Procedure.A pair of one male and one female homozygote were used to reproduce 4.1R knock out mice and C57BL/6J mic... |
| Keywords: | gene knock out mouse protein 4 1R |
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