黄芪对儿童变应性鼻炎血清Th1/Th2的影响

目的通过观察黄芪对变应性鼻炎患儿的Th1/Th2细胞因子的影响,探讨黄芪对变应性鼻炎的作用机制。方法60例变应性鼻炎患儿随机分黄芪治疗组和常规治疗对照组。两组均采用常规治疗,治疗组加用黄芪颗粒1/2包(7.5g),3次/d,疗程2￣6个月。观察患儿2个月内总有效率及用药前和用药2个月后血清Th1和Th2基因表达和蛋白产生水平的变化。结果2个月后黄芪治疗组总有效率显著高于常规治疗组,差异有统计学意义(χ2=0.666,P<0.05),用药后黄芪治疗组、常规治疗组血清Th1比例上升显著,高于健康对照组;用药后黄芪治疗组、常规治疗组Th2比例下降显著(P<0.05),而黄芪治疗组显著高于常规治疗组(P<0.05)。结论黄芪能纠正变应性鼻炎患儿体内Th1/Th2细胞因子的失衡状态,提高缓解率。

Effect of supplementary therapy with astragalus on serum Th1/Th2 in children with allergic rhinitis

Objective To study the supplementary therapy effect with astragalus in allergic rhinitis (AR) on the changes of Th1/Th2 . Methods Sixty children with AR were randomly divided into treatment group (30 cases) and control group (30 cases) with general treatment.The 7.5 g(1/2 bag) astragalus by three times a day was added orally to treatment group for 2 to 6 months. The total effective rates within 2 months were observed in both treatment group and control group. The expression and production levels of IL-2,IL-4,IL-10,IFN-γ were determined before astragalus being used and 2 months after the usage. And then the changes in serum IL-2,IL-4,IL-10,IFN-γ were observed in treatment group and control group. Results The rate of total effective within 2 months was higher in treatment group than control group (P<0.05).The expression and production level of serum Th1/Th2 was singnificantly higher in treatment group than that in control group (P<0.01),and different in astragalus treatment group in comparison with general control group (P<0.05).Conclusion Astraglus therapy can be helpful in adjusting the level of serum Th1/Th2 of children with AR.