15N-Tracertechnische Untersuchungen zum Eiweißstoffwechsel bei Arteriosklerosepatienten

Summary The incorporation of the stable isotope¹⁵N in plasma proteins and blood cells after oral application of 3 g¹⁵NH₄Cl (95 At%¹⁵N) per 70 kg body weight was followed up in 11 patients with ischemic heart disease or peripheral arteriosclerosis and in 7 healthy control subjects. Preliminary results indicate that the turnover of plasma protein, especially fibrin, is elevated in patients with arteriosclerosis. Investigations of platelets intimate a decreased turnover of platelet protein in patients with arteriosclerosis as compared to control subjects. Possible reasons for these alterations are discussed.