Pentraxin 3蛋白在乳腺癌中的表达及其临床意义

目的:探究炎症因子五聚蛋白3（Pentraxin3，PTX3）在乳腺癌中的表达及其临床意义。方法:选取2004—2012年的309例乳腺浸润性导管癌（IDC）患者乳腺癌组织以及33例癌旁组织石蜡标本，通过免疫组织化学染色分析PTX3蛋白在乳腺癌中的表达。结果:PTX3蛋白在乳腺癌组织中较癌旁表达更高（χ2 =35.3，P<0.001），其表达水平与肿瘤的组织学级别呈正相关（r=0.139，P<0.05）；Kaplan-Meier生存分析表明，PTX3蛋白是乳腺癌患者总生存（χ2 =5.708，P<0.05）及无进展生存（χ2 =4.958，P<0.05）的独立预后因素，PTX3高表达的乳腺癌患者预后更差。结论:PTX3蛋白在乳腺癌中高表达，且与乳腺癌的组织学级别呈正相关，PTX3高表达的患者预后差，PTX3可以作为乳腺癌精准治疗的潜在靶标。

The expression and clinical significance of Pentraxin 3 in breast cancer

Objective: To explore the expression and clinical significance of inflammatory factor Pentraxin 3 （PTX3） in breast cancer. Methods: A total of 309 breast cancer tissues from breast invasive ductal carcinoma （IDC） patients and 33 adjacent normal tissues paraffin specimens ranged from 2004 to 2012 were selected. The expression of PTX3 in breast cancer were analyzed by immunohistochemical staining. Results: Analysis of clinical samples showed that the expression of PTX3 in breast cancer tissues was higher than that in adjacent normal tissues（χ2=35.3，P<0.001） and its expression level was positively correlated with the histological grade of breast cancer（r=0.139，P<0.05）. Kaplan-Meier survival analysis showed that the protein level of PTX3 was an independent predictor of overall survival（χ2 =5.708，P<0.05） and progression-free survival（χ2 =4.958，P<0.05） in patients with breast cancer. Breast cancer patients with higher PTX3 expression had a worse prognosis. Conclusion: PTX3 protein is highly expressed in breast cancer and is positively correlated with the histological grade of breast cancer. Patients with high level of PTX3 have poor prognosis. PTX3 can be used as a potential target for precise breast cancer treatment.