Retrospective study of selective neck dissection versus radical neck dissection as salvage therapy for patients with recurrent nasopharyngeal squamous cell carcinoma |
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| Affiliation: | 1. Department of Head and Neck Surgery, Fuzhou General Hospital, Nanjing Command Zone of PLA, Fuzhou, China;2. Department of Bioinformatics, Fuzhou General Hospital, Nanjing Command Zone of PLA, Fuzhou, China;3. Department of Oncology, Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350112, China;1. Department of Otolaryngology, Head and Neck Surgery, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan;2. Department of Pathology, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan;3. Department of Otolaryngology, Head and Neck Surgery, National Taiwan University Hospital, School of Medicine, National Taiwan University, Taipei, Taiwan;1. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Nazloo Road, Urmia 57153 1177, Iran;2. Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;3. Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada;1. Department of Plastic and Reconstructive Surgery, Chiba University, Graduate School of Medicine, Japan;2. Department of Neurosurgery, Showa University, Japan;1. Physics and Astronomy Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;2. Czestochowa University of Technology, Armii Krajowej 17, 42-200 Czestochowa, Poland;3. Lviv National University of Veterinary Medicine and Biotechnologies, Department of Inorganic and Organic Chemistry, 79010 Lviv, Ukraine;4. Max Plank Institute for Solid State Research, Heisenberg Str. 1, D-70569 Stuttgart, Germany;5. Physics Department, Helwan University, 11792 Cairo, Egypt;6. Physics Deparment, Faculty of Science, Ain Shams University, Abassia, Cairo 11566, Egypt |
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| Abstract: | PurposeWhile salvage surgery has been shown to improve the survival of patients with recurrent nasopharyngeal carcinoma, it is not known whether selective neck dissection has a beneficial or harmful effect on the survival of patients compared with modified neck dissection. The present study was aimed to compare the outcomes among patients receiving either selective neck dissection or modified neck dissection as salvage therapy for recurrent nasopharyngeal carcinoma.Patients and methodsIn the present retrospective study, a total of 67 patients with recurrent nasopharyngeal squamous cell carcinoma were included. 23 patients received selective neck dissection and 44 patients received modified neck dissection. The clinical parameters and Kaplan–Meier 1-, 3-, 5-year overall survivals were compared for the two groups.ResultsThe clinical parameters were comparable between the two groups. The 1-, 3-, 5-year survivals were 91.3%, 62.0% and 55.1% respectively for selective neck dissection and 93.1%, 82.5% and 77.9% respectively for modified neck dissection. Patients receiving modified neck dissection had a significant better overall survival than patients receiving selective neck dissection (χ2 = 4.079, P = 0.043).ConclusionAlthough selective neck dissection was associated with fewer complications, it was associated with poor over all survival compared with modified neck dissection. Further prospective, large-scale and long-term study is needed to confirm this conclusion. |
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| Keywords: | Nasopharyngeal carcinoma Selective neck dissection Modified neck dissection |
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