乳腺粘液癌超声特征及免疫组化指标

  目的  分析乳腺粘液癌的超声图像特征及免疫组化指标，提高诊断粘液癌的准确性。  方法  回顾性分析56例乳腺癌肿块的超声特征（肿块最大径、纵横比、高回声晕、转移情况、弹性评分等）、剪切波速度（SWV_max、SWV_ratio、SWV_mean）及免疫组化检测结果（雌激素受体、孕激素受体、人表皮生长因子受体2、Ki-67），将粘液癌患者作为实验组（n=24），将浸润性导管癌患者作为对照组（n=32），对比两组超声特征及免疫组化指标表达的差异性，并对超声特征及免疫组化指标进行相关性分析。  结果  与浸润性导管癌相比，粘液癌肿块多表现为边界清晰、有高回声晕、后方回声增强、弹性评分 < 4分且BI-RADS分类 < 4b类（χ2=4.419、5.171、6.162、4.743、14.000，P < 0.05），SWV_max及雌激素受体、人表皮生长因子受体2的阳性率在两组中的差异具有统计学意义（t=- 2.069，χ2=4.371、4.051，P < 0.05）。  结论  乳腺粘液癌超声特征及免疫组化指标的表达与浸润性导管癌相比具有一定的差异，可为超声诊断乳腺癌类型及治疗方案的选择提供参考。 

Ultrasonographic features and immunohistochemical parameters of mucinous Carcinoma of breast

  Objective  To analyze the ultrasonographic features and immunohistochemical indexes of mucinous carcinoma of the breast, and improve the accuracy in the diagnosis of mucinous carcinoma.  Methods  The ultrasonographic features (maximum diameter, aspect ratio, high echo halo, metastasis, elastic score), shear wave velocity (SWV_max, SWV_ratio, SWV_mean) and immunohistochemical detection (ER, PR, HER-2, Ki-67) of 56 cases were analyzed retrospectively. 24 cases with mucinous carcinoma were used as experimental group and 32 cases with invasive ductal carcinoma were used as control group.The differences of ultrasonic features and immunohistochemical indexes between the two groups were compared. The correlation between ultrasonic features and immunohistochemical indexes was analyzed.  Results  Compared with invasive ductal carcinoma, mucinous carcinoma showed clear boundary, high echo halo, posterior echo enhancement, less than 4 score and BI-RADS classification < 4b (χ2=4.419, 5.171, 6.162, 4.743, 14.000, P < 0.05). The positive rates of SWV_max, ER and HER-2 were significantly different between the two groups (t=-2.069, χ2=4.371, 4.051, P < 0.05).  Conclusion  Compared with invasive ductal carcinoma, the expression of ultrasound features and immunohistochemical markers in mucinous carcinoma of breast are different, which can provide reference for the diagnosis and treatment of mucinous Carcinoma of breast.