高血压脑出血患者应激性高血糖与微创碎吸术后血清炎性细胞因子水平的相关性研究

目的观察高血压脑出血患者应激性高血糖对微创碎吸术后血清细胞因子水平的影响。方法80例高血压脑出血患者按入院24小时内血糖分为正常血糖组（56例）和高血糖组（24例），同时选10例健康人血清做对照，连续监测血清中肿瘤坏死因子a（TNFα）、白细胞介素6（IL-6）的动态变化。结果两组患者的TNFa、IL-6含量均高于健康对照组。正常血糖组患者其TNFa、IL-6含量达峰时间早。高血糖组患者TNFa、IL-6含量达峰时间较晚，且TNFa、IL-6水平较高。结论脑出血患者血浆炎性细胞因子水平水平升高与应激反应有关，且对预后产生不利影响。

Investigation of stress hyperglycemia and inflammatory cytokines in hypertensive cerebral hemorrhage after micro-injury operations

Objective To investigate the effect of stress hyperglycemia on inilammatory cytosines m serum oi hypertensive cerebral hemorrhage after micro-injury operations. Methods 80 patients accepted micro-injury operation according their blood glucose with 24 hours after their enrollment were divided two groups., hyperglycemia group （n=24） and normoglycemia group （n= 56）. 10 serum samples of healthy persons were tested as control. The changes of TNFa, IL-6 were observed continuously. Results The levels of TNFa,II.-6 of patients are higher than that of healthy control. That of group hyperglycemia was higher than normoglycemia group. Patients＇ peak levels of TNFa,IL-6 of appeared earlier in hyperglycemia group than normoglycemia group. Conclusion There is a relationship between the high level of in- flammatory cytokines in serum and stress hyperglycemia and stress hyperglycemia makes the curative effect worse.