| 正交试验优选复方岩白菜素滴丸制备工艺 |
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| 引用本文： | 金杨,王燕. 正交试验优选复方岩白菜素滴丸制备工艺[J]. 中国药房, 2011, 0(7): 614-615 |
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| 作者姓名： | 金杨 王燕 |
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| 作者单位： | 云南大理州中医医院;大理学院药学院; |
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| 摘 要： | 目的:确立复方岩白菜素滴丸的最佳制备工艺。方法:采用L9(34)正交试验,以滴丸的溶散时限和外观评分为指标,以基质种类、药物与基质的用量比、药液温度、冷凝剂种类为考察因素,优选最佳成型工艺;以滴丸重量变异系数为指标,以滴头口径、滴速、冷却剂温度、滴距为考察因素,优选最佳滴制工艺。结果:最佳制备工艺是基质为聚乙二醇6000,药物与基质配比为1∶2,药液温度为(70±0.5)℃,冷却剂为液体石蜡,滴头内外径为2.0mm/3.0mm,滴速为60d·min-1,滴距为6cm,冷却剂温度为(10±0.5)℃。结论:该制备工艺稳定、可行、重现性好,所得制剂成型性好。
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| 关 键 词： | 复方岩白菜素滴丸 成型工艺 聚乙二醇 正交试验 |
Optimization of the Preparation Technology of Compound Bergenin Dripping Pills by Orthogonal Design |
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| JIN Yang WANG Yan. Optimization of the Preparation Technology of Compound Bergenin Dripping Pills by Orthogonal Design[J]. China Pharmacy, 2011, 0(7): 614-615 |
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| Authors: | JIN Yang WANG Yan |
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| Affiliation: | JIN Yang(Chinese Medicine Hospital of Dali Prefecture,Dali 671000,China) WANG Yan(College of Pharmacy,Dali University,China) |
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| Abstract: | OBJECTIVE: To optimize the preparation technology of Compound bergenin dripping pills. METHODS: The forming technology of Compound bergenin dripping pills was optimized by L9(34) orthogonal design with dissolution time and appearance score as index using type of matrix, ratio of drug to matrix, mixture temperature, type of condensing agent as factors. The dripping technology of Compound bergenin dripping pills was optimized using weight variation as index and with diameter of burette, dripping speed, temper... |
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| Keywords: | Compound bergenin dripping pills Forming technology PEG Orthogonal design |
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