| 马兜铃酸A在中药饮片及其配方颗粒中的含量分析 |
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| 引用本文： | 黄国鑫,倪晨,李一圣,易宇阳,张仲敏,赵学军,苏子仁. 马兜铃酸A在中药饮片及其配方颗粒中的含量分析[J]. 中国实验方剂学杂志, 2011, 17(14): 75-78 |
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| 作者姓名： | 黄国鑫 倪晨 李一圣 易宇阳 张仲敏 赵学军 苏子仁 |
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| 作者单位： | 广州中医药大学中药学院,广州,510006 |
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| 摘 要： | 目的:对5种马兜铃科中药饮片及配方颗粒(由相应批次的中药饮片制成)所含马兜铃酸A进行含量测定。方法:采用高效液相色谱法,YMC-Pack C18色谱柱(4.6 mm×250 mm,5μm),流动相甲醇(A)-0.05%磷酸溶液(B),检测波长250nm,流速0.8 mL.min-1,柱温30℃。结果:5种马兜铃科中药饮片(各3批)中马兜铃酸A平均质量分数分别为关木通4.18mg.g-1,马兜铃0.77 mg.g-1,蜜马兜铃0.46 mg.g-1,青木香0.86 mg.g-1,寻骨风0.53 mg.g-1;5种中药配方颗粒(n=3)马兜铃酸A平均质量分数分别为关木通1.16 mg.g-1,马兜铃0.31 mg.g-1,蜜马兜铃0.10 mg.g-1,青木香0.39 mg.g-1,寻骨风0.03 mg.g-1。结论:建立的方法对多种含马兜铃酸A药材与配方颗粒具有较好的适应性,可以用于其含量测定;中药配方颗粒的制作工艺对中药饮片的成分有一定影响,有必要建立相关生产监控标准、质量控制标准,用来保证中药配方颗粒的质量。
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| 关 键 词： | 马兜铃酸A 中药饮片 中药配方颗粒 |
| 收稿时间： | 2010-12-22 |
Assaying of Aristolochic Acid A in Chinese Herbal Pieces and the Traditional Chinese Medicine Particle |
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| HUANG Guo-xin,NI Chen,LI Yi-sheng,YI Yu-yang,ZHANG Zhong-min,ZHAO Xue-jun and SU Zi-ren. Assaying of Aristolochic Acid A in Chinese Herbal Pieces and the Traditional Chinese Medicine Particle[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(14): 75-78 |
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| Authors: | HUANG Guo-xin NI Chen LI Yi-sheng YI Yu-yang ZHANG Zhong-min ZHAO Xue-jun SU Zi-ren |
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| Affiliation: | School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;School of Traditionl Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China |
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| Abstract: | |
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| Keywords: | aristolochic acid A Chinese herbal pieces traditional Chinese medicine particle |
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