生地马钱丸配合来氟米特治疗类风湿性关节炎50例

目的:观察中药生地马钱丸配合来氟米特治疗类风湿性关节炎(RA)的疗效及安全性。方法:90例RA患者随机分为两组,对照组40例患者给予来氟米特口服以及对症治疗;治疗组50例在对照组治疗的基础上口服生地马钱丸,3 g/次,3次/d。两组疗程均为6个月。监测治疗前后临床疗效指标的变化及药物的不良反应。结果:治疗组总有效率显著高于对照组(P<0.05);两组在关节疼痛数、关节压痛积分、关节肿胀积分、晨僵时间及20 m步行时间等及血沉(ESR),慢反应物质(CRP)方面均与用药前比较有显著改善(P<0.05或P<0.01),且治疗组均优于对照组(P<0.05,P<0.01);口服生地马钱丸未发生明显的不良反应。结论:生地马钱丸配合来氟米特治疗RA疗效优于单用来氟米特,且安全性好。

Effect of Habitat Strychnos Pill Combined with Leflunomide for Treatment of Rheumatoid Arthritis

Objective: To observe the efficacy and safety of Habitat Strychnos pill Combined with leflunomide for the treatment of rheumatoid arthritis (RA). Method: Ninety cases of RA were randomly divided into 2 groups, control group(40 cases) given leflunomide with oral, as well as symptomatic treatment; the treatment group (50 cases)received oral Chinese medicine Habitat Strychnos pill on the basis of therapy in the control group. The course of treatment was 6 months. Before and after treatment changes in indicators of clinical efficacy and adverse drug reactions were monitored. Result: The treatment group was significantly higher than the control group for the total effective rate (P<0.05). Compared with pre-treatment, the treatment significantly improved efficacy in the number of joint pain, joint tenderness score, joint swelling score, morning stiffness time and 20 m walking time, ESR,CRP (P<0.05 or P <0.01). Oral medicine pills habitat Strychnos did not show obvious side effects. Conclusion :Habitat Strychnos pill with leflunomide for the treatment of RA is more effective than leflunomide alone, and the safety is good.