| 丹参注射液及其活性成分丹参素、原儿茶醛对人红细胞胞浆Ca2+浓度影响的实验研究 |
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| 引用本文： | 沈玲红,王彬尧,王长谦,谢秀兰,俞国瑞,姚中一,朱元龙,杨葆津.丹参注射液及其活性成分丹参素、原儿茶醛对人红细胞胞浆Ca2+浓度影响的实验研究[J].中国中药杂志,2004,29(10):984-988. |
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| 作者姓名： | 沈玲红 王彬尧 王长谦 谢秀兰 俞国瑞 姚中一 朱元龙 杨葆津 |
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| 作者单位： | 1. 上海第二医科大学,附属仁济医院,心内科,上海,200001
2. 上海本草生物医学工程研究所,上海,200040 |
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| 摘 要： | 目的 :探讨丹参水溶性部位钙拮抗作用的主要有效成分。方法 :采用荧光探针Fura-2定量分析法 ,分别测定丹参注射液及其活性成分丹参素、原儿茶醛对离体健康成人红细胞胞浆Ca2+ 浓度的影响。结果 :丹参素和原儿茶醛均有降低成人红细胞胞浆Ca2+ 浓度的作用 ,并表现出剂量依赖性 ,二者合并用药 ,药效相加 ,作用与丹参注射液相似。结论 :丹参素和原儿茶醛可能是丹参注射液钙拮抗作用的主要有效成分。
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| 关 键 词： | 丹参注射液 丹参素 原儿茶醛 钙离子 红细胞 |
| 文章编号： | 1001-5302(2004)10-0984-05 |
| 收稿时间： | 2003/9/18 0:00:00 |
Effect of danshensu, protocatechualdehyde and Danshen injection on calciumion concentration in cytoplasm of human erythrocytes |
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| SHEN Ling-hong ;WANG Bin-yao ;WANG Chang-qian ;XIE Xiu -lan ;YU Guo-rui ;YAO Zhong-yi ;ZHU Yuan-long ;YANG Bao-jin.Effect of danshensu, protocatechualdehyde and Danshen injection on calciumion concentration in cytoplasm of human erythrocytes[J].China Journal of Chinese Materia Medica,2004,29(10):984-988. |
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| Authors: | SHEN Ling-hong ;WANG Bin-yao ;WANG Chang-qian ;XIE Xiu -lan ;YU Guo-rui ;YAO Zhong-yi ;ZHU Yuan-long ;YANG Bao-jin |
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| Institution: | Department of Cadiology, Renji Hospital of Shanghai Second Medical University, Shanghai 200001, China. shenlinghong@medmail.com.cn |
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| Abstract: | Objective: To study the predominant calcium-an ta gonist components of Danshen injection. Method:The effects of danshensu, protocatechualdehyde and Danshen injection on calcium concentratio n in cytoplasm of erythrocytes were examined in vitro by the fluorescent Ca2+-chelator fura-2. Result: Either DS182 or PCAD can d ecrease in dose-dependent cytosolic free calcium concentration in human erythro cytes. They had additive effect when mixed, which was similar to Danshen inje ction. Conclusion: DS182 and PCAD may be predominant calcium- antagonist components of Danshen injection. |
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| Keywords: | Danshen injection danshensu protocatechuald ehyde Ca2+ erythrocyte |
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