| IL－2／TNF／LAK／TIL治疗晚期肺癌的近期疗效及免疫机理研究 |
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| 引用本文： | 周建英,刘敬东,程瑛,何正善,孙永良,姚航平,林舜华,何南祥.IL－2／TNF／LAK／TIL治疗晚期肺癌的近期疗效及免疫机理研究[J].浙江大学学报(医学版),1995(2). |
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| 作者姓名： | 周建英 刘敬东 程瑛 何正善 孙永良 姚航平 林舜华 何南祥 |
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| 作者单位： | 浙江医科大学附属第一医院肺科，浙江医科大学传染病研究所免疫研究室 |
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| 摘 要： | 作者报道用ＩＬ－２／ＴＮＦ／ＬＡＫ／ＴＩＬ治疗３０例失去手术机会和不能耐受全程化疗的晚期肺癌的结果。该法总有效率（ＣＲ＋ＰＲ）达４３．３％，９例伴有恶性胸水者经ＩＬ－２／ＴＮＰ／ＴＩＬ局部胸腔治疗后显效５例，有效４例。文中对该疗法的免疫机理作了初步探讨。
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| 关 键 词： | 支气管肿瘤／治疗 支气管肿瘤／免疫疗法 白细胞介素2／治疗应用 肿瘤坏死因子／治疗应用 杀伤细胞 |
EFFICACY AND IMMUNOLOGICAL MECHANISM OF IL-2/TNF/LAK/TIL IN TREATMENT OF LUNG CARCINOMA |
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| Zhou Jianying,Liu Jingdong,Cheng Ying,et al.EFFICACY AND IMMUNOLOGICAL MECHANISM OF IL-2/TNF/LAK/TIL IN TREATMENT OF LUNG CARCINOMA[J].Journal of Zhejiang University(Medical Sciences),1995(2). |
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| Authors: | Zhou Jianying Liu Jingdong Cheng Ying |
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| Abstract: | The patients with advanced lung carcinoma who did not accept operations or respond to chemotherapy were treated with interleukin-2(IL-2) /tumor necrosis factor(TNF )/lymphokine-activated killing cells(LAK)and tumor infiltrating lymphocytes(TIL). The response rate (CR PR)was 43.3%. Among them 9 patients with malignant pleural effusion underwent intrapleural administration of IL-2/TNF/TIL. Pleural effusion disappeared completely in 5 cases,and almost completely in 4.The immunological mechanism of this therapy was also discussed. |
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| Keywords: | Bronchial neoplasms/ther Bronchial neoplasms/immunotherapy Interleukin 2/ther use Tumor necrosis factor/ther use Killes cells |
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