MCM2 - a promising marker for premalignant lesions of the lung: a cohort study |
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| Authors: | Dong-Feng Tan Joel A Huberman Andrew Hyland Gregory M Loewen John SJ Brooks Amy F Beck Ivan T Todorov Gerold Bepler |
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| Affiliation: | (1) Lung Cancer Program, Roswell Park Cancer Institute, 14263 Buffalo, NY, USA;(2) Department of Diabetes, Endocrinology and Metbabolism, City of Hope Medical Centre, 91010 Duarte, CA, USA |
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| Abstract: | ![]()
Background Because cells progressing to cancer must proliferate, marker proteins specific to proliferating cells may permit detection of premalignant lesions. Here we compared the sensitivities of a classic proliferation marker, Ki-67, with a new proliferation marker, MCM2, in 41 bronchial biopsy specimens representing normal mucosa, metaplasia, dysplasia, and carcinoma in situ. |
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