| 氧化应激与脑缺血-再灌注损伤 |
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| 引用本文： | 王钊,黄雨蒙. 氧化应激与脑缺血-再灌注损伤[J]. 国际病理科学与临床杂志, 2012, 32(4): 343-346. DOI: 10.3969/j.issn.1673-2588.2012.04.014 |
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| 作者姓名： | 王钊 黄雨蒙 |
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| 作者单位： | 1.中南大学湘雅医学院,长沙,410013;2.中南大学湘雅医学院,长沙,410013 |
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| 基金项目： | 中南大学大学生创新训练项目 |
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| 摘 要： | 脑缺血-再灌注损伤是一个复杂的级联反应过程,涉及多种机制,其中氧化应激起到关键作用.目前的研究表明,氧化应激可以通过脂质过氧化、蛋白质变性和/或DNA修饰等途径促使神经细胞坏死,也可以通过线粒体、内质网或死亡受体等途径启动神经细胞凋亡.本文就氧化应激在脑缺血-再灌注损伤中的作用机制及抗氧化治疗的新进展作一综述.
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| 关 键 词： | 脑缺血-再灌注损伤 氧化应激 抗氧化治疗 |
Oxidative stress and cerebral ischemia-reperfusion injury |
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| WANG Zhao , HUANG Yumeng. Oxidative stress and cerebral ischemia-reperfusion injury[J]. Journal of International Pathology and Clinical Medicine, 2012, 32(4): 343-346. DOI: 10.3969/j.issn.1673-2588.2012.04.014 |
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| Authors: | WANG Zhao HUANG Yumeng |
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| Affiliation: | 1.Grade 2007,Eight-year System,Xiangya School of Medicine,Central South University,Changsha 410013; 2.Department of Pharmacology,Central South University,Changsha 410078,China) |
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| Abstract: | Cerebral ischemia-reperfusion injury is a complex cascade of reactions involving a variety of mechanisms,among which oxidative stress plays a key role.Recent studies suggest that oxidative stress may promote neuronal necrosis via lipid peroxidation,protein degeneration,and/or DNA modification.Oxidative stress can also trigger neuronal apoptosis through the mitochondrial pathway,the endoplasmic reticulum pathway,or the death receptor pathway.This review focuses on the mechanisms of oxidative stress during cerebral ischemia-reperfusion injury and the progress made in its treatment with antioxidants. |
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| Keywords: | cerebral ischemia-reperfusion injury oxidative stress antioxidant treatment |
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