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Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus |
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| Authors: | Sayaka Matsumoto Hiroshi Ogawa Satoshi Soda Satoshi Hirayama Najith Amarasena Yoshifusa Aizawa Hideo Miyazaki |
| Affiliation: | Divison of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Gakkocho-Dori Niigata, Japan;;Department of Endocrinology and Metabolism, Niigata City General Hospital, Japan;;Department of Endocrinology and Metabolism, Niigata University Medical and Dental Hospital, Japan;;Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka;;Division of Cardiology, Hematology and Endocrinology/Metabolism, Department of Homeostatic Regulation and Developments, Graduate School of Medical and Dental Sciences, Niigata University, Gakkocho-Dori Niigata, Japan |
| Abstract: | Aims: The aims of this study were to evaluate the effect of mechanical periodontal treatment with local application of minocycline (APT) on serum adiponectin as a marker of insulin resistance improvement in type 2 diabetes mellitus (T2DM) patients and to investigate if effect of APT on serum adiponectin level was sustained by periodontal maintenance (PM). Material and Methods: Twenty-seven T2DM patients were randomly assigned into test or control groups. Test received scaling with ultrasonic devices at baseline and APT biweekly for 2 months while control received scaling at baseline and mechanical tooth cleaning (MPT) at the same interval. At 6 months, all patients received mechanical tooth cleaning as PM. Periodontal examination and blood measurements were performed at baseline, 4 and 9 months. Results: Adiponectin concentrations in test had significantly increased by 31.4% after APT ( p =0.024) and by 30.4% after PM ( p =0.002) compared with baseline. The percentage of 4 mm probing depths (PD) had shown 8.3% and 9.3% reduction after APT and PM ( p =0.046, 0.02) in test while 5.0% reduction after MPT in control group ( p =0.031). Conclusions: Our results suggested that APT and PM not only improve periodontal disease but also increase serum adiponectin in T2DM patients. |
| Keywords: | adiponectin antimicrobial periodontal treatment insulin resistance periodontal disease periodontal maintenance randomized controlled trial type 2 diabetes mellitus |