艾可清胶囊对HIV感染者T淋巴细胞亚群的影响

目的：评价艾可清胶囊对HIV感染者T淋巴细胞亚群的影响。方法：采用描述性研究,纳入2004年1月-2009年5月期间在广州市第八人民医院感染科就诊的HIV感染者,给予艾可清胶囊治疗,在治疗前（M0）、治疗后第6（M6）、12（M12）、18（M18）、24个月（M24）分别进行T淋巴细胞亚群检测,统计方法采用配对样本t检验和可重复测量资料的单因素方差分析。结果：共有40例患者纳入研究,分别以M6、M12、M18、M24为终点时点进行分析,结果显示：以M6为终点时点时,CD3较M0显著升高（P〈0.01）,CD4、CD8升高,CD4/CD8下降,但变化均无统计学意义（P〉0.05）。可重复测量的单因素方差分析显示CD3、CD4、CD8在以M12、M18、M24为结局的各时点之间变化无统计学意义（P〉0.05）;CD4/CD8在M12为终点的各时点之间变化显著（P〈0.01）,经多重分析显示,M12时点较M0显著下降（P〈0.01）,而在以M18、M24为结局的各时点之间变化无统计学意义（P〉0.05）。结论：经24个月的远期疗效观察,艾可清胶囊可使无症状期HIV感染者CD3水平在治疗6个月后明显升高并保持良好稳定,使CD4和CD8水平持续稳定。艾可清胶囊延缓HIV感染者进入发病期的疗效肯定。

Effects of Aikeqing Capsule on T Lymphocyte Subsets in HIV Infectors

Objective：To evaluate effects of Aikeqing Capsule on T Lymphocyte Subsets in HIV Infectors.Methods：HIV Infectors included between Jan of 2008 and Jul of 2009 received Aikeqing Capsule and have T lymphocyte subsets detected at Month0,1,6,12,18,24. Paired-Samples T test and one-way ANOVA were used in statistical analysis. Results：Comparing M6 with M0,CD3 increased significantly （P0.01）,while other changes were not significant：CD4 and CD8 increased,CD4/CD8 decreased （P0.05）. Decreases of CD3、CD4、CD8 between baseline and M12、M18、M24 were not different statistically（P0.05）. Changes of CD4/CD8 was significant only when using M12 as endpoint（P0.01）.Conclusion：Aikeqing Capsule can significantly increase CD3 levels in asymptomatic HIV-infectors after 3-month treatment,and stabilize CD3,CD4,CD8 levels. So Aikeqing Capsule has a definite slowing down effect for progression the infection.