BRMS1、HDAC1、VEGF-C在乳腺癌组织中的表达及意义

目的探讨BRMS1、HDAC1及VEGF-C蛋白在乳腺癌、乳房纤维瘤及正常乳腺组织的表达及意义。方法采用免疫组织化学方法随机检测60例乳腺癌组织标本BRMS1、HDAC1、VEGF-C蛋白的表达,随机收集乳房纤维瘤组织及其旁正常乳腺组织各20例作为对照组,结合临床病理资料分析其临床意义。结果BRMS1在乳腺癌组织中表达率为60%,在乳房纤维瘤组织中表达率为85%,在正常乳腺组织中表达率为95%,乳腺癌组织中的BRMS1的表达明显低于乳房纤维瘤和正常乳腺组织(P0.05)。HDAC1在乳腺癌组织中表达率为91.7%,在乳房纤维瘤组织中表达率为55%,在正常乳腺组织中表达45%,HDAC1在乳腺癌组织中的表达明显高于乳房纤维瘤和正常乳腺组织(P0.01),乳腺癌中VEGF-C的表达58.3%高于乳房纤维瘤25%和正常组织20%(P0.05)。结论BRMS1、HDAC1和VEGF-C共同参与了乳腺癌的转移,联合检测BRMS1、HDAC1及VEGF-C的表达有助于判断其预后。

Expression and Significance of BRMS1, HDAC1 and VEGF-C in Breast Cancer

Objective To investigate the expression and clinical significance of breast cancer metastasis suppressor 1 （BRMS1）protein, histone deacetylase 1 （HDAC1） and vascular endothelial cell growth factor-C （VEGF-C） protein in breast cancer. Methods The expression of BRMS1 protein,HDAC1 and VEGF-C was detected by using immunohistochemical technique in 60 cases of breast cancer,20 cases of breast fibroids and 20 cases of adjacent normal breast tissue as control and the clinical significance was analyzed with histopalthological records. Results The positive rate of BRMS1 expression was 60% in breast cancer tissue,85% in breast fibroids and 95% in normal breast tissue,show- ing the positive rate of BRMSI in breast cancer was much lower than that in breast fibroids and normal breast tissue（P〈O.05）. The positive rate of HDAC1 expression was 91.7% in breast cancer,55% breast fibroids and 45% in normal breast tissue,showing the positive rate of HDAC1 in breast cancer was obviously higher than that in breast fibroids and normal breast tissue（P〈0.01 ）. The positive rate of VEGF-C expression was 58.3% in breast cancer, 25% in breast fibroids and 20% in normal breast tissue（P〈0.05）. Conclusion BRMS1, HDAC1 and VEGF-C might synergistically promote the metastasis of breast cancer. Therefore,the combined detection of the expression of BRMS1 HDAC 1 and VEGF-C may be helpful in the determination of the prognosis of breast cancer.