E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer

Authors:	Ladu Sara Calvisi Diego F Conner Elizabeth A Farina Miriam Factor Valentina M Thorgeirsson Snorri S

Affiliation:	Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4262, USA.

Abstract:

Keywords:	4E-BP1, eukaryotic initiation factor 4E binding protein 1 AODN, antisense oligodeoxy nucleotides ASK1, apoptosis signal-regulating kinase-1 DAPK, death-associated protein kinase HCC, hepatocellular carcinoma HCCB, hepatocellular carcinoma with better prognosis HCCP, hepatocellular carcinoma with poor prognosis mTOR, mammalian target of rapamycin p70 S6K, p70 ribosomal protein S6 kinase PI3K, phosphatidylinositol 3-kinase PIK3CA, catalytic subunit p110α of phosphatidylinositol 3-kinase Rheb, Ras homologue enriched in brain rpS6, ribosomal protein S6 TopBP1, topoisomerase (DNA) II β binding protein TSC2, tuberin
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