T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome |
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| Authors: | Elham Barkhordari Nima Rezaei Mahdi Mahmoudi Pegah Larki Hamid Reza Ahmadi-Ashtiani Bita Ansaripour Maryam Alighardashi Mohammad Bashashati Ali Akbar Amirzargar Naser Ebrahimi-Daryani |
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| Affiliation: | (1) Molecular Immunology Research Center and Immunogenetic Laboratory, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;(2) Growth and Development Research Center, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;(3) Biochemistry & Nutrition Department, Zanjan Medical University, Zanjan, Iran;(4) Clinical Biochemistry Department, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran;(5) Gastrointestinal Research Group, University of Calgary, Calgary, AB, Canada;(6) Department of Gastroenterology and Hepatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | ![]()
Inflammation and mucosal immune system activation have an important role in irritable bowel syndrome (IBS), whereas genetic factors can control some immunological mediators. In this study, a number of polymorphic genes coding for T-helper 1, T-helper 2, and T-regulatory cytokines were genotyped in 71 patients with IBS, and the results were compared with controls. IL-4 CC genotype at position −590, IL-4 TT genotype at position −33, and IL-10 GA genotype at position −1082 were significantly overrepresented in the patients with IBS in comparison with controls (P < 0.001). The frequencies of the following haplotypes in the patient group were significantly higher than in the control group: IL-2 (−330, +160) GT haplotype (P = 0.002), IL-4 (−1098, −590, −33) TCC haplotype (P < 0.001), and TCT haplotype (P < 0.001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS. |
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