E试验测定78株念珠菌属真菌对4种抗真菌药物的敏感性

目的 检测4种抗真菌药物对念珠菌属真菌的最低抑菌浓度（MIC）并分析其耐药性。方法 用E试验检测两性霉素B（AP）、酮康唑（KE）、氟康唑（FL）、伊曲康唑（IT）对78株临床分离的念珠菌属真菌的MIC值。结果 78株念珠菌属真菌对AP、KE、FL、IT的总敏感率分别是89．7％、92．3％、85．9％、85．9％；白念珠菌对AP、KE、FL和IT的敏感率分别是96．9％、96．9％、100％和87．5％。结论 4种药物对白念珠菌的体外抗菌活性均较好，但对非白念珠菌的抗菌活性则较前者为差。

Susceptibility of 78 Candida strains to 4 antifungal agents tested by E test

Objective This study was designed to determine MICs of 4 antifungal agents against Candida isolates and evaluate drug resistance in Candida spp.Methods MICs of amphotericin B (AP), ketoconazole (KE), fluconazole (FL), itraconazole (IT) were determined on 78 clinical isolates of Candida by E test.Results The susceptibility rate of 78 strains of Candida to AP, KE, FL, IT was 89.7%, 92.3%, 85.9% and 85.9% respectively. The susceptibility rate of Candida albicans to the above 4 antifungal agents was 96.9%, 96.9%, 100% and 87.5% accordingly.Conclusions The 4 antifungal agents tested have good antifungal activity against Candida albicans in vitro. Their antifungal activity against other Candida spp. is not as good as against Candida albicans.