| 耐多药肺结核患者抗二线结核药的耐药分析 |
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| 引用本文： | 杜凤华,陶满意,张雷,李玉勤. 耐多药肺结核患者抗二线结核药的耐药分析[J]. 临床肺科杂志, 2014, 0(9): 1646-1648 |
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| 作者姓名： | 杜凤华 陶满意 张雷 李玉勤 |
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| 作者单位： | 杜凤华(安徽省胸科医院, 安徽 合肥,230022)；陶满意(安徽省胸科医院, 安徽 合肥,230022)；张雷(安徽省胸科医院, 安徽 合肥,230022)；李玉勤(安徽省胸科医院, 安徽 合肥,230022)； |
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| 摘 要： | 目的了解耐多药肺结核患者对二线抗结核药物的耐药情况。方法对我院住院的341例耐多药肺结核患者二线抗结核药物的耐药情况进行分析。结果 341例MDR-TB对左氧氟沙星、丙硫异烟胺、力克肺疾、对氨基水杨酸、丁胺卡那霉素、卷曲霉素的总耐药率依次为49.9%、26.4%、24.9%、23.4%、18.5%、15.8%。复治组对二线抗结核药物的耐多药率明显高于初治组,不合理治疗是形成MDR-TB或XDRTB的主要原因。结论耐多药肺结核患者对二线抗结核药物耐药情况严重,要引起重视。
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| 关 键 词： | 结核分枝杆菌 肺结核 耐多药 耐二线药 |
Analysis of drug resistance of MDR-TB patients to second-line drugs |
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| Affiliation: | DU Feng-hua, TAO Man-yi (Anhui Chest Hospital, Hefei, Anhui 230022, China) |
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| Abstract: | Objective To study the drug resistance of MDR-TB patients to second-line drug. Methods The drug resistance of 341 MDR-TB patients to second-line drug was analyzed in our hospital. Results The drug re-sistance rate of 341 MDR-TB patients to levofloxacin, prothionamide, isoniazid aminosalicylate, P-aminosalicylic acid, amikacin and capreomycin were 49. 9%, 26. 4%, 24. 9%, 3. 4%, 18. 5% and 15. 8% respectively. The multi-drug resistant rate of second-line anti-TB drugs in the retreatment group was higher than that in the initial treat-ment group. Unreasonable treatment was the main reason for the formation of MDR-TB or XDR-TB. Conclusion The drug resistance of MDR-TB patients to second-line drug is in serious condition, which must be paid more atten-tion. |
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| Keywords: | mycobacterium tuberculosis pulmonary tuberculosis MDR resistance to second-line drug |
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