| 二氢叶酸还原酶抑制剂:5-取代苯硫基(硒基)-2,4-二氨基嘧啶类化合物的合成和抑酶活性 |
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| 引用本文： | 仉文陞,李仁利,王庆军.二氢叶酸还原酶抑制剂:5-取代苯硫基(硒基)-2,4-二氨基嘧啶类化合物的合成和抑酶活性[J].药学学报,1987(2). |
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| 作者姓名： | 仉文陞 李仁利 王庆军 |
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| 作者单位： | 北京医科大学药化教研室，北京医科大学药化教研室，北京医科大学药化教研室 79级毕业生 |
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| 摘 要： | 甲氧苄胺嘧啶(Trimethoprim,TMP,I)为抗菌增效剂,已广泛用于临床。它是一种有高度选择性的二氢叶酸还原酶(DHFR)抑制剂。为进一步提高其生物活性,对结构改造和构效关系等方面进行了大量的工作。报道了其结构中苄基苯环上取代基的改变,虽有少数
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| 关 键 词： | 二氢叶酸还原酶抑制剂 5-取代苯硫基-2 4-二氨基嘧啶类化合物 5-取代苯硒基-2 4-二氨基嘧啶类化合物 |
STUDIES ON THE SYNTHESIS OF DIHYDROFOLATE REDUCTASE INHIBITOR,5-(SUBSTITUTED PHENYL)-THIO(SELENO)-2,4-DIAMINOPYRIMIDINES AND THEIR INHIBITORY ACTIVITY TO L.CASEI AND CHICKEN LIVER DHFR |
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| ZHANG Wen-Sheng,LI Ren-Li and WANG Qing-Jun.STUDIES ON THE SYNTHESIS OF DIHYDROFOLATE REDUCTASE INHIBITOR,5-(SUBSTITUTED PHENYL)-THIO(SELENO)-2,4-DIAMINOPYRIMIDINES AND THEIR INHIBITORY ACTIVITY TO L.CASEI AND CHICKEN LIVER DHFR[J].Acta Pharmaceutica Sinica,1987(2). |
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| Authors: | ZHANG Wen-Sheng LI Ren-Li and WANG Qing-Jun |
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| Abstract: | |
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| Keywords: | Dihydrofolate reductase inhibitor 5-(Substituted phenyl) thio-2 4-diaminopyrimidine 5-(Substituted phenyl) seleno-2 4-diaminopyrimidine |
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